ENK2_HUMAN » HERV-K_7p22.1 provirus ancestral Env polyprotein

ENK2_HUMAN » HERV-K_7p22.1 provirus ancestral Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENK2_HUMAN » HERV-K_7p22.1 provirus ancestral Env polyprotein » EnvK2 protein;Envelope polyprotein;HERV-K(C7) envelope protein;HERV-K(HML-2.HOM) envelope protein;HERV-K108 envelope protein;
Hydrophobic Thickness 31.2 ± 1.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -41.1 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 636-657 (635-662)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 114-283, Retro-transcribing viruses envelope glycoprotein

AA: 486-683, Retroviral envelope protein

UniProt annotation for ENK2_HUMAN » HERV-K_7p22.1 provirus ancestral Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.

FUNCTION: SU mediates receptor recognition.

FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

TISSUE SPECIFICITY: Expressed in testis, and peripheral blood lymphocytes.

MISCELLANEOUS: Two human-specific proviruses are inserted as tandem repeats with a shared LTR in most individuals tested. The telomeric copy is referred here as "provirus 41574". The centromeric copy is referred here as "provirus 41575".

MISCELLANEOUS: ERVK-6 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5"-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.

UniProt features for ENK2_HUMAN » HERV-K_7p22.1 provirus ancestral Env polyprotein
SIGNAL 1 89 Potential.
CHAIN 90 699 HERV-K_7p22.1 provirus ancestral Env polyprotein.
CHAIN 90 465 Surface protein (By similarity).
CHAIN 466 699 Transmembrane protein (By similarity).
REGION 466 486 Fusion peptide (Potential).
SITE 465 466 Cleavage (By similarity).
Amino Acid Sequence for ENK2_HUMAN » HERV-K_7p22.1 provirus ancestral Env polyprotein
MNPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEEQMKLP STKKAEPPTW AQLKKLTQLA TKYLENTKVT QTPESMLLAA LMIVSMVVSL PMPAGAAAAN YTYWAYVPFP PLIRAVTWMD NPTEVYVNDS VWVPGPIDDR CPAKPEEEGM MINISIGYHY PPICLGRAPG CLMPAVQNWL VEVPTVSPIC RFTYHMVSGM SLRPRVNYLQ DFSYQRSLKF RPKGKPCPKE IPKESKNTEV LVWEECVANS AVILQNNEFG TIIDWAPRGQ FYHNCSGQTQ SCPSAQVSPA VDSDLTESLD KHKHKKLQSF YPWEWGEKGI STPRPKIVSP VSGPEHPELW RLTVASHHIR IWSGNQTLET RDRKPFYTID LNSSLTVPLQ SCVKPPYMLV VGNIVIKPDS QTITCENCRL LTCIDSTFNW QHRILLVRAR EGVWIPVSMD RPWEASPSVH ILTEVLKGVL NRSKRFIFTL IAVIMGLIAV TATAAVAGVA LHSSVQSVNF VNDWQKNSTR LWNSQSSIDQ KLANQINDLR QTVIWMGDRL MSLEHRFQLQ CDWNTSDFCI TPQIYNESEH HWDMVRRHLQ GREDNLTLDI SKLKEQIFEA SKAHLNLVPG TEAIAGVADG LANLNPVTWV KTIGSTTIIN LILILVCLFC LLLVCRCTQQ LRRDSDHRER AMMTMAVLSK RKGGNVGKSK RDQIVTVSV