ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein

ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein » EnvK1 protein;Envelope polyprotein;
Hydrophobic Thickness 31.2 ± 1.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -41.1 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 635-656 (634-661)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 113-282, Retro-transcribing viruses envelope glycoprotein

AA: 485-682, Retroviral envelope protein

UniProt annotation for ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.

FUNCTION: SU mediates receptor recognition.

FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

MISCELLANEOUS: ERVK-21 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5"-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.

UniProt features for ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein
SIGNAL 1 88 Potential.
CHAIN 89 698 HERV-K_12q14.1 provirus ancestral Env polyprotein.
CHAIN 89 464 Surface protein (By similarity).
CHAIN 465 698 Transmembrane protein (By similarity).
REGION 465 485 Fusion peptide (Potential).
SITE 464 465 Cleavage (By similarity).
Amino Acid Sequence for ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein
MHPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEQMKLPS TKKAEPPTWA QLKKLTQLAT KYLENTKVTQ TPESMLLAAL MIVSMVVSLP MPAGAAAANY TNWAYVPFPP LIRAVTWMDN PIEVYVNDSV WVHGPIDDRC PAKPEEEGMM INISIGYHYP PICLGRAPGC LMPAVQNWLV EVPTVSPISR FTYNMVSGMS LRPRVNYLQD FSYQRSLKFR PKGKPCPKEI PKESKNTEVL VWEECVANSV VILQNNEFGT IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV DSDLTESLDK HKHKKLQSFY PWEWGEKGIS TPRPKIISPV SGPEHPELWR LTVASHHIRI WSGNQTLETR DRKPFYTVDL NSSLTVPLQS CVKPPYMLVV GNIVIKPDSQ TITCENCRLL TCIDSTFNWQ HRILLVRARE GVWIPVSMDR PWEASPSIHI LTEVLKGVLN RSKRFIFTLI AVIMGLIAVT AMAAVAGVAL HSFVQSVNFV NDWQKNSTRL WNSQSSIDQK LANQINDLRQ TVIWMGDRLM SLEHRFQLQC DWNTSDFCIT PQIYNESEHH WDMVRRHLQG REDNLTLDIS KLKEQIFEAS KAHLNLVPGT EAIAGVADGL ANLNPVTWVK TIGSTTIINL ILILVCLFCL LLVCRCTQQL RRDSDHRERA MMTMVVLSKR KGGNVGKSKR DQIVTVSV