|ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein » EnvK1 protein;Envelope polyprotein;|
|Hydrophobic Thickness||31.2 ± 1.6 Å|
|Tilt Angle||1 ± 0°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||635-656 (634-661)|
AA: 113-282, Retro-transcribing viruses envelope glycoprotein
AA: 485-682, Retroviral envelope protein
|UniProt annotation for ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein|
|FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. FUNCTION: SU mediates receptor recognition. FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity). MISCELLANEOUS: ERVK-21 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5"-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.|
|UniProt features for ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein|
SIGNAL 1 88 Potential. |
CHAIN 89 698 HERV-K_12q14.1 provirus ancestral Env polyprotein.
CHAIN 89 464 Surface protein (By similarity).
CHAIN 465 698 Transmembrane protein (By similarity).
REGION 465 485 Fusion peptide (Potential).
SITE 464 465 Cleavage (By similarity).
|Amino Acid Sequence for ENK1_HUMAN » Endogenous retrovirus group K member 21 Env polyprotein|
|MHPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEQMKLPS TKKAEPPTWA QLKKLTQLAT KYLENTKVTQ TPESMLLAAL MIVSMVVSLP MPAGAAAANY TNWAYVPFPP LIRAVTWMDN PIEVYVNDSV WVHGPIDDRC PAKPEEEGMM INISIGYHYP PICLGRAPGC LMPAVQNWLV EVPTVSPISR FTYNMVSGMS LRPRVNYLQD FSYQRSLKFR PKGKPCPKEI PKESKNTEVL VWEECVANSV VILQNNEFGT IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV DSDLTESLDK HKHKKLQSFY PWEWGEKGIS TPRPKIISPV SGPEHPELWR LTVASHHIRI WSGNQTLETR DRKPFYTVDL NSSLTVPLQS CVKPPYMLVV GNIVIKPDSQ TITCENCRLL TCIDSTFNWQ HRILLVRARE GVWIPVSMDR PWEASPSIHI LTEVLKGVLN RSKRFIFTLI AVIMGLIAVT AMAAVAGVAL HSFVQSVNFV NDWQKNSTRL WNSQSSIDQK LANQINDLRQ TVIWMGDRLM SLEHRFQLQC DWNTSDFCIT PQIYNESEHH WDMVRRHLQG REDNLTLDIS KLKEQIFEAS KAHLNLVPGT EAIAGVADGL ANLNPVTWVK TIGSTTIINL ILILVCLFCL LLVCRCTQQL RRDSDHRERA MMTMVVLSKR KGGNVGKSKR DQIVTVSV|