ENK14_HUMAN » Endogenous retrovirus group K member 13-1 Env polyprotein

ENK14_HUMAN » Endogenous retrovirus group K member 13-1 Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENK14_HUMAN » Endogenous retrovirus group K member 13-1 Env polyprotein » Envelope polyprotein;
Hydrophobic Thickness 31.4 ± 2.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -21.0 kcal/mol
ΔGfold -17.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 460-481 (460-481)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 5-109, Retro-transcribing viruses envelope glycoprotein

AA: 310-482, Retroviral envelope protein

UniProt annotation for ENK14_HUMAN » Endogenous retrovirus group K member 13-1 Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity).

FUNCTION: SU mediates receptor recognition.

FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

TISSUE SPECIFICITY: Primary culture of CD34+, lung, thymus, ileal mucosa, small intestine, and testis.

UniProt features for ENK14_HUMAN » Endogenous retrovirus group K member 13-1 Env polyprotein
CHAIN 1 482 HERV-K_16p3.3 provirus ancestral Env polyprotein.
CHAIN 1 289 Surface protein (By similarity).
CHAIN 290 482 Transmembrane protein (By similarity).
REGION 290 310 Fusion peptide (Potential).
SITE 289 290 Cleavage (By similarity).
Amino Acid Sequence for ENK14_HUMAN » Endogenous retrovirus group K member 13-1 Env polyprotein
MWTVPSFTND SYQVYNVFST NSFQLLTVKR TPHEAWRVPL TTKTNKTKGL PDCPKKPTNG PFIVTSILWD NCNAPKAVVL QTLAMGIVID WAPKGHYWQD CSSKNTLCSE FIYSLDYIEH GWQSYTMRQR VSPYPFKWMD TGIAPPRPKI IHPFFTPEHP ELWKLAAALS GIKIWNTTYQ LLRTKTKTPT FNITLISEWV IPIRSCVKPP YMLLVGNIIM MPDAQTIECH NCKLFTCIDA TFNPTTSILL VRAREGVWIP VSLHRPWESS PSIHIVNEVL KDILKRTKRF IFTLIAVLAG LLAVTATAAT AGVAIRSSVQ TAHYVEACQK NSSRLWNSQA QIDQKLANQI NDLRQSVTWL GDRVMNLQHR MQLQCDWNTS DYCITPYAYN QDQHSWENVS RHLKAWDDNL TLDISQLKEQ IFEASQAHLS TVPGSHIFEG ITKQLPDFNP FKWLKPVRGS LLLLALLILV CLCCLLLVCR CL