ENK12_HUMAN » HERV-K_1q22 provirus ancestral Env polyprotein

ENK12_HUMAN » HERV-K_1q22 provirus ancestral Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENK12_HUMAN » HERV-K_1q22 provirus ancestral Env polyprotein » Envelope polyprotein;HERV-K(III) envelope protein;HERV-K102 envelope protein;
Hydrophobic Thickness 31.2 ± 1.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -41.1 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 525-546 (524-551)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 3-172, Retro-transcribing viruses envelope glycoprotein

AA: 375-572, Retroviral envelope protein

UniProt annotation for ENK12_HUMAN » HERV-K_1q22 provirus ancestral Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.

FUNCTION: SU mediates receptor recognition.

FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

TISSUE SPECIFICITY: Expressed in lung, placenta, testis and peripheral blood lymphocytes.

MISCELLANEOUS: This envelope protein is encoded by a human specific provirus.

MISCELLANEOUS: Has a type 1 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5"-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.

UniProt features for ENK12_HUMAN » HERV-K_1q22 provirus ancestral Env polyprotein
CHAIN 1 588 HERV-K_1q22 provirus ancestral Env polyprotein.
CHAIN 1 354 Surface protein (By similarity).
CHAIN 355 588 Transmembrane protein (By similarity).
REGION 355 375 Fusion peptide (Potential).
SITE 354 355 Cleavage (By similarity).
Amino Acid Sequence for ENK12_HUMAN » HERV-K_1q22 provirus ancestral Env polyprotein
MVTPVTWMDN PIEIYVNDSV WVPGPIDDRC PAKPEEEGMM INISIGYRYP PICLGRAPGC LMPAVQNWLV EVPTVSPISR FTYHMVSGMS LRPRVNYLQD FSYQRSLKFR PKGKPCPKEI PKESKNTEVL VWEECVANSA VILQNNEFGT IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV DSDLTESLDK HKHKKLQSFY PWEWGEKRIS TPRPKIVSPV SGPEHPELWR LTVASHHIRI WSGNQTLETR DCKPFYTIDL NSSLTVPLQS CVKPPYMLVV GNIVIKPDSQ TITCENCRLL SCIDSTFNWQ HRILLVRARE GVWIPVSMDR PWEASPSVHI LTEVLKGVLN RSKRFIFTLI AVIMGLIAVT ATAAVAGVAL HSSVQSVNFV NDWQKNSTRL WNSQSSIDQK LANQINDLRQ TVIWMGDRLM SLEHRFQLQC DWNTSDFCIT PQIYNESEHH WDMVRRHLQG REDNLTLDIS KLKEQIFEAS KAHLNLVPGT EAIAGVADGL ANLNPVTWVK TIGSTTIINL ILILVCLFCL LLVCRCTQQL RRDSDHRERA MMTMAVLSKR KGGNVGKSKR DQIVTVSV