ENK11_HUMAN » HERV-K_22q11.21 provirus ancestral Env polyprotein

ENK11_HUMAN » HERV-K_22q11.21 provirus ancestral Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENK11_HUMAN » HERV-K_22q11.21 provirus ancestral Env polyprotein » Envelope polyprotein;HERV-K101 envelope protein;
Hydrophobic Thickness 31.2 ± 1.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -41.1 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 525-546 (524-551)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 1-146, Retro-transcribing viruses envelope glycoprotein

UniProt annotation for ENK11_HUMAN » HERV-K_22q11.21 provirus ancestral Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity).

TISSUE SPECIFICITY: Cerebellum and testis.

MISCELLANEOUS: Intergenic, closest flanking genes being GSTM1 and GSTM5.

UniProt features for ENK11_HUMAN » HERV-K_22q11.21 provirus ancestral Env polyprotein
CHAIN 1 588 HERV-K_22q11.21 provirus ancestral Env polyprotein.
CHAIN 1 354 Surface protein (By similarity).
CHAIN 355 588 Transmembrane protein (By similarity).
REGION 355 375 Fusion peptide (Potential).
SITE 354 355 Cleavage (By similarity).
Amino Acid Sequence for ENK11_HUMAN » HERV-K_22q11.21 provirus ancestral Env polyprotein
MVTPVTWMDN PIEVYVNDSE WVPGPTDDRC PAKPEEEGMM INISIGYRYP PICLGTAPGC LMPAVQNWLV EVPIVSPISR FTYHMVSGMS LRPRVNYLQD FPYQRSLKFR PKGKPCPKEI PKESKNTEVL VWEECVANSA VILQNNEFGT IIDWAPRGQF YHNCSGQTQS CPSAQVSPAV DSDLTESLDK HKHKKLQSFY PWEWGEKGIS TPRPKIISPV SGPEHPELWR LTVASHHIRI WSGNQTLETR DRKPFYTVDL NSSLTLPLQS CVKPPYMLVV GNIVIKPDSQ TITCENCRLL TCIDSTFNWQ HRILLVRARE GVWILVSMDR PWEASPSVHI LTEVLKGVLN RSKRFIFTLI AVIMGLIAVT ATGAVAGVAL HSSVQSVNFV NDWQKNSTRL WNSQSSIDQK LANQINDLRQ TVIWMGDRLM SLEHRFQLQC DWNTSDFCIT PQIYNESEHH WDMVRHHLQG REDNLTLDIS KLKEQIFEAS KAHLNLVPGT EAIAGVADGL ANLNPVTWVK TIGSTTIINL ILILVCLFCL LLVCRCTQQL RRDSDHRERA MMTMAVLSKR KGGNVGKSKR DQIVTVSV