ENH3_HUMAN » HERV-H_2q24.1 provirus ancestral Env polyprotein

ENH3_HUMAN » HERV-H_2q24.1 provirus ancestral Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ENH3_HUMAN » HERV-H_2q24.1 provirus ancestral Env polyprotein » Env protein HERV-H/p59;Envelope polyprotein;HERV-H/env59;
Hydrophobic Thickness 35.2 ± 1.6 Å
Tilt Angle 39 ± 0°
ΔGtransfer -34.1 kcal/mol
ΔGfold -15.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 510-540 (510-547)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 247-544, PDBID: 1XNL, Subunit A, Seq Identity:87%, ENV polyprotein (coat polyprotein)

UniProt annotation for ENH3_HUMAN » HERV-H_2q24.1 provirus ancestral Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.

FUNCTION: SU mediates receptor recognition.

FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

TISSUE SPECIFICITY: Low expression in testis.

MISCELLANEOUS: Orthologs in Pan troglodytes, Gorilla gorilla (truncated) and Pongo pygmaeus (truncated).

MISCELLANEOUS: HERV-H family subgenomic RNAs have been observed.

MISCELLANEOUS: This provirus is intergenic, the closest flanking genes being KCNJ3 and NR4A2.

UniProt features for ENH3_HUMAN » HERV-H_2q24.1 provirus ancestral Env polyprotein
SIGNAL 1 35 Potential.
CHAIN 36 555 HERV-H_2q24.1 provirus ancestral Env polyprotein.
CHAIN 36 387 Surface protein (By similarity).
CHAIN 388 555 Transmembrane protein (By similarity).
REGION 388 408 Fusion peptide (By similarity).
MOTIF 64 67 CXXC (By similarity).
SITE 387 388 Cleavage (By similarity).
Amino Acid Sequence for ENH3_HUMAN » HERV-H_2q24.1 provirus ancestral Env polyprotein
MILAGRAPSN TSTLMKFYSL LLYSLLFSFP FLYHPLPLPS YLHHTINLTH SLPAASNPSL ANNCWLCISL SSSAYIAVPT LQTDRATSPV SLHLRTSFNS PHLYPPEELI YFLDRSSKTS PDISHQPAAA LLHIYLKNLS PYINSTPPIF GPLTTQTTIP VAAPLCISRQ RPTGIPLGNI SPSRCSFTLH LQSPTTHVTE TIGVFQLHII DKPSINTDKL KNVSSNYCLG RHLPYISLHP WLPSPCSSDS PPRPSSCLLT PSPQNNSERL LVDTQRFLIH HENRTSSSMQ LAHQSPLQPL TAAALAGSLG VWVQDTPFST PSHPFSLHLQ FCLTQGLFFL CGSSTYMCLP ANWTGTCTLV FLTPKIQFAN GTKELPVPLM TLTPQKRVIP LIPLMVGLGL SASTIALSTG IAGISTSVTT FRSPSNDFSA SITDISQTLS VLQAQVDSLA AVVLQNRRGL GLSILLNEEC CFYLNQSGLV YENIKKLKDR AQKLANQASN YAESPWALSN WMSWVLPILS PLIPIFLLLL FGPCIFHLVS QFIQNRIQAI TNHSI