EMP46_YEAST » Protein EMP46

EMP46_YEAST » Protein EMP46
Magnify EMP46_YEAST » Protein EMP46Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
EMP46_YEAST » Protein EMP46 » 46 kDa endomembrane protein;
Hydrophobic Thickness 34.8 ± 2.4 Å
Tilt Angle 8 ± 6°
ΔGtransfer -26.3 kcal/mol
ΔGfold -23.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 410-432 (406-439)
Pathways none
PDB 2a6v (52-275), 2a6w (52-275), 2a6x (52-275)
OPM none
Complexes none
Interactions

EMP47, Complex: EMP46:EMP47, PubMed

MKAR, Complex: MKAR:EMP46, PubMed

MTC4, Complex: MTC4:EMP46

PMP2, Complex: EMP46:PMP2, PubMed

Domains

AA: 52-270, PDBID: 2A6V, Subunit B, Seq Identity:100%, Legume-like lectin family

UniProt annotation for EMP46_YEAST » Protein EMP46
FUNCTION: Involved in the secretion of glycoproteins and in nucleus architecture and gene silencing.

SUBUNIT: Interacts with EMP47 in the endoplasmic reticulum membrane in order to be transported to the Golgi apparatus. Interacts with the coatomer proteins COP1, SEC21 and SEC23.

DOMAIN: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

UniProt features for EMP46_YEAST » Protein EMP46
SIGNAL 1 46
CHAIN 47 444 Protein EMP46.
DOMAIN 52 269 L-type lectin-like.
REGION 429 432 Mediates the interactions with COPI and COPII coat complexes.
MOTIF 440 444 Di-lysine motif.
DISULFID 196 230
Amino Acid Sequence for EMP46_YEAST » Protein EMP46
MTTRKTASSL QLLGKITGTK AGTKQKKMNF INGLIWLYMC VWMVHGKVTQ KDELKWNKGY SLPNLLEVTD QQKELSQWTL GDKVKLEEGR FVLTPGKNTK GSLWLKPEYS IKDAMTIEWT FRSFGFRGST KGGLAFWLKQ GNEGDSTELF GGSSKKFNGL MILLRLDDKL GESVTAYLND GTKDLDIESS PYFASCLFQY QDSMVPSTLR LTYNPLDNHL LKLQMDNRVC FQTRKVKFMG SSPFRIGTSA INDASKESFE ILKMKLYDGV IEDSLIPNVN PMGQPRVVTK VINSQTGEES FREKMPFSDK EESITSNELF EKMNKLEGKI MANDIDPLLR KMNKIVENER ELIQRLRPLL DLKKTAISDD SFQDFLSMNA NLDRLIKEQE KIRQDAKLYG KQTKGHDEIF SKISVWLALL IFIMITLAYY MFRINQDIKK VKLL