EMC1_YEAST » ER membrane protein complex subunit 1

EMC1_YEAST » ER membrane protein complex subunit 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
EMC1_YEAST » ER membrane protein complex subunit 1 »
Hydrophobic Thickness 30.2 ± 1.9 Å
Tilt Angle 7 ± 4°
ΔGtransfer -24.2 kcal/mol
ΔGfold -10.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 724-744 (723-745)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CUE1, Complex: EMC1:CUE1

HLJ1, Complex: EMC1:HLJ1

IRE1, Complex: IRE1:EMC1

SCS2, Complex: SCS2:EMC1

TLG2, Complex: TLG2:EMC1

VOA1, Complex: EMC1:VOA1

YL312, Complex: YL312:EMC1, PubMed

Domains

AA: 538-757, Protein of unknown function (DUF1620)

UniProt annotation for EMC1_YEAST » ER membrane protein complex subunit 1
FUNCTION: The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

SUBUNIT: Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.

MISCELLANEOUS: Present with 2840 molecules/cell in log phase SD medium.

UniProt features for EMC1_YEAST » ER membrane protein complex subunit 1
SIGNAL 1 24 Potential.
CHAIN 25 760 ER membrane protein complex subunit 1.
Amino Acid Sequence for EMC1_YEAST » ER membrane protein complex subunit 1
MKITCTDLVY VFILLFLNTS CVQAVFSDDA FITDWQLANL GPWEKVIPDS RDRNRVLILS NPTETSCLVS SFNVSSGQIL FRNVLPFTID EIQLDSNDHN AMVCVNSSSN HWQKYDLHDW FLLEEGVDNA PSTTILPQSS YLNDQVSIKN NELHILDEQS KLAEWKLELP QGFNKVEYFH REDPLALVLN VNDTQYMGFS ANGTELIPVW QRDEWLTNVV DYAVLDVFDS RDVELNKDMK AELDSNSLWN AYWLRLTTNW NRLINLLKEN QFSPGRVFTK LLALDAKDTT VSDLKFGFAK ILIVLTHDGF IGGLDMVNKG QLIWKLDLEI DQGVKMFWTD KNHDELVVFS HDGHYLTIEV TKDQPIIKSR SPLSERKTVD SVIRLNEHDH QYLIKFEDKD HLLFKLNPGK NTDVPIVANN HSSSHIFVTE HDTNGIYGYI IENDTVKQTW KKAVNSKEKM VAYSKRETTN LNTLGITLGD KSVLYKYLYP NLAAYLIANE EHHTITFNLI DTITGEILIT QEHKDSPDFR FPMDIVFGEY WVVYSYFSSE PVPEQKLVVV ELYESLTPDE RLSNSSDNFS YDPLTGHINK PQFQTKQFIF PEIIKTMSIS KTTDDITTKA IVMELENGQI TYIPKLLLNA RGKPAEEMAK DKKKEFMATP YTPVIPINDN FIITHFRNLL PGSDSQLISI PTNLESTSII CDLGLDVFCT RITPSGQFDL MSPTFEKGKL LITIFVLLVI TYFIRPSVSN KKLKSQWLIK