EMB_HUMAN » Embigin

EMB_HUMAN » Embigin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EMB_HUMAN » Embigin »
Hydrophobic Thickness 30.0 ± 3.2 Å
Tilt Angle 9 ± 3°
ΔGtransfer -37.7 kcal/mol
ΔGfold -14.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 261-285 (261-289)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 71-156, PDBID: 4LL9, Subunit C, Seq Identity:25%, Immunoglobulin domain

AA: 159-254, PDBID: 1KOA, Subunit A, Seq Identity:23%, Immunoglobulin I-set domain

UniProt annotation for EMB_HUMAN » Embigin
FUNCTION: Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).

SUBUNIT: Interacts with SLC16A1 and SLC16A7.

UniProt features for EMB_HUMAN » Embigin
SIGNAL 1 32 Potential.
CHAIN 33 327 Embigin.
DOMAIN 71 158 Ig-like V-type 1.
DOMAIN 159 253 Ig-like V-type 2.
DISULFID 88 142 By similarity.
DISULFID 180 237 By similarity.
Amino Acid Sequence for EMB_HUMAN » Embigin
MRALPGLLEA RARTPRLLLL QCLLAAARPS SADGSAPDSP FTSPPLREEI MANNFSLESH NISLTEHSSM PVEKNITLER PSNVNLTCQF TTSGDLNAVN VTWKKDGEQL ENNYLVSATG STLYTQYRFT IINSKQMGSY SCFFREEKEQ RGTFNFKVPE LHGKNKPLIS YVGDSTVLTC KCQNCFPLNW TWYSSNGSVK VPVGVQMNKY VINGTYANET KLKITQLLEE DGESYWCRAL FQLGESEEHI ELVVLSYLVP LKPFLVIVAE VILLVATILL CEKYTQKKKK HSDEGKEFEQ IEQLKSDDSN GIENNVPRHR KNESLGQ