ELFN1_HUMAN » Protein ELFN1

ELFN1_HUMAN » Protein ELFN1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ELFN1_HUMAN » Protein ELFN1 » Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1;Protein phosphatase 1 regulatory subunit 28;
Hydrophobic Thickness 35.6 ± 3.4 Å
Tilt Angle 16 ± 11°
ΔGtransfer -25.3 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 415-440 (414-451)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 84-144, PDBID: 4BSR, Subunit B, Seq Identity:42%, Leucine rich repeat

AA: 133-192, PDBID: 4Z0C, Subunit D, Seq Identity:41%, Leucine rich repeat

UniProt annotation for ELFN1_HUMAN » Protein ELFN1
FUNCTION: Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

SUBUNIT: Interacts with PPP1CA.

UniProt features for ELFN1_HUMAN » Protein ELFN1
SIGNAL 1 27 Potential.
CHAIN 28 806 Protein ELFN1.
REPEAT 61 82 LRR 1.
REPEAT 85 106 LRR 2.
REPEAT 109 130 LRR 3.
REPEAT 133 154 LRR 4.
REPEAT 157 178 LRR 5.
DOMAIN 190 252 LRRCT.
DOMAIN 312 399 Fibronectin type-III.
REPEAT 318 342 LRR 6.
Amino Acid Sequence for ELFN1_HUMAN » Protein ELFN1
MAGRGWGALW VCVAAATLLH AGGLARADCW LIEGDKGFVW LAICSQNQPP YEAIPQQINS TIVDLRLNEN RIRSVQYASL SRFGNLTYLN LTKNEIGYIE DGAFSGQFNL QVLQLGYNRL RNLTEGMLRG LGKLEYLYLQ ANLIEVVMAS SFWECPNIVN IDLSMNRIQQ LNSGTFAGLA KLSVCELYSN PFYCSCELLG FLRWLAAFTN ATQTYDRMQC ESPPVYSGYY LLGQGRRGHR SILSKLQSVC TEDSYAAEVV GPPRPASGRS QPGRSPPPPP PPEPSDMPCA DDECFSGDGT TPLVALPTLA TQAEARPLIK VKQLTQNSAT ITVQLPSPFH RMYTLEHFNN SKASTVSRLT KAQEEIRLTN LFTLTNYTYC VVSTSAGLRH NHTCLTICLP RLPSPPGPVP SPSTATHYIM TILGCLFGMV LVLGAVYYCL RRRRRQEEKH KKAASAAAAG SLKKTIIELK YGPELEAPGL APLSQGPLLG PEAVTRIPYL PAAGEVEQYK LVESADTPKA SKGSYMESSV AEISTIAKEV DKVNQIINNC IDALKSESTS FQGVKSGPVS VAEPPLVLLS EPLAAKHGFL APGYKDAFGH SLQRHHSVEA AGPPRASTSS SGSVRSPRAF RAEAVGVHKA AAAEAKYIEK GSPAADAILT VTPAAAVLRA EAEKGRQYGE HRHSYPGSHP AEPPAPPGPP PPPPHEGLGR KASILEPLTR PRPRDLAYSQ LSPQYHSLSY SSSPEYTCRA SQSIWERFRL SRRRHKEEEE FMAAGHALRK KVQFAKDEDL HDILDYWKGV SAQHKS