EGF_HUMAN » Pro-epidermal growth factor

EGF_HUMAN » Pro-epidermal growth factor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EGF_HUMAN » Pro-epidermal growth factor » EGF;
Hydrophobic Thickness 34.0 ± 1.2 Å
Tilt Angle 2 ± 2°
ΔGtransfer -43.0 kcal/mol
ΔGfold -25.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 1030-1053 (1029-1060)
Pathways

Bladder cancer (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Endocytosis (KEGG)

Endometrial cancer (KEGG)

ErbB signaling pathway (KEGG)

Focal adhesion (KEGG)

Gap junction (KEGG)

Glioma (KEGG)

Hemostasis (Reactome)

Hepatitis C (KEGG)

HIF-1 signaling pathway (KEGG)

Immune System (Reactome)

MAPK signaling pathway (KEGG)

Melanoma (KEGG)

Non-small cell lung cancer (KEGG)

Pancreatic cancer (KEGG)

Pathways in cancer (KEGG)

PI3K-Akt signaling pathway (KEGG)

Prostate cancer (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB 2kv4 (971-1023), 1p9j (976-1022), 1jl9 (A/B=971-1021), 1nql (B=971-1023), 1ivo (C/D=971-1023), 3njp (C/D=975-1021)
OPM none
Complexes

EGF:EGFR_HUMAN

Interactions

ADA12, Complex: EGF:ADA12, PubMed

EGFR, Complex: EGF:EGFR, PubMed

EGFR, Complex: EGFR:EGF, PDBID: 1ivo

EMD, Complex: EMD:EGF, PubMed

ERBB2, Complex: ERBB2:EGF, PubMed

ERBB3, Complex: EGF:ERBB3, PubMed

NRG1, Complex: EGF:NRG1, PubMed

TGFA, Complex: EGF:TGFA, PDBID: 1gk5

Domains

AA: 356-395, PDBID: 1LMJ, Subunit A, Seq Identity:44%, Calcium-binding EGF domain

AA: 524-564, PDBID: 3S2K, Subunit A, Seq Identity:55%, Low-density lipoprotein receptor repeat class B

AA: 567-607, PDBID: 3S94, Subunit B, Seq Identity:44%, Low-density lipoprotein receptor repeat class B

AA: 610-651, PDBID: 3V64, Subunit D, Seq Identity:51%, Low-density lipoprotein receptor repeat class B

AA: 654-694, PDBID: 3V64, Subunit D, Seq Identity:56%, Low-density lipoprotein receptor repeat class B

AA: 745-780, PDBID: 3S94, Subunit A, Seq Identity:48%, Coagulation Factor Xa inhibitory site

AA: 870-910, PDBID: 1UZJ, Subunit B, Seq Identity:45%, Calcium-binding EGF domain

AA: 912-948, PDBID: 1H30, Subunit A, Seq Identity:49%, Calcium-binding EGF domain

AA: 976-1011, PDBID: 1IVO, Subunit D, Seq Identity:100%, EGF-like domain

UniProt annotation for EGF_HUMAN » Pro-epidermal growth factor
FUNCTION: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed).

SUBUNIT: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD).

TISSUE SPECIFICITY: Expressed in kidney, salivary gland, cerebrum and prostate.

DISEASE: Hypomagnesemia 4 (HOMG4) OMIM: A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. is caused by mutations affecting the gene represented in this entry.

UniProt features for EGF_HUMAN » Pro-epidermal growth factor
SIGNAL 1 22 Potential.
CHAIN 23 1207 Pro-epidermal growth factor.
CHAIN 971 1023 Epidermal growth factor.
REPEAT 86 127 LDL-receptor class B 1.
REPEAT 128 169 LDL-receptor class B 2.
REPEAT 170 211 LDL-receptor class B 3.
REPEAT 212 258 LDL-receptor class B 4.
DOMAIN 314 355 EGF-like 1.
DOMAIN 356 396 EGF-like 2; calcium-binding (Potential).
DOMAIN 397 437 EGF-like 3.
DOMAIN 435 477 EGF-like 4.
REPEAT 483 523 LDL-receptor class B 5.
REPEAT 524 566 LDL-receptor class B 6.
REPEAT 567 609 LDL-receptor class B 7.
REPEAT 610 653 LDL-receptor class B 8.
REPEAT 654 696 LDL-receptor class B 9.
DOMAIN 741 781 EGF-like 5.
DOMAIN 831 869 EGF-like 6.
DOMAIN 870 911 EGF-like 7; calcium-binding (Potential).
DOMAIN 912 952 EGF-like 8; calcium-binding (Potential).
DOMAIN 972 1013 EGF-like 9.
REGION 801 807 O-glycosylated at one site.
DISULFID 318 330 By similarity.
DISULFID 325 339 By similarity.
DISULFID 341 354 By similarity.
DISULFID 360 371 By similarity.
DISULFID 367 380 By similarity.
DISULFID 382 395 By similarity.
DISULFID 401 412 By similarity.
DISULFID 408 421 By similarity.
DISULFID 423 436 By similarity.
DISULFID 439 451 By similarity.
DISULFID 447 461 By similarity.
DISULFID 463 476 By similarity.
DISULFID 745 756 By similarity.
DISULFID 752 765 By similarity.
DISULFID 767 780 By similarity.
DISULFID 835 846 By similarity.
DISULFID 840 855 By similarity.
DISULFID 857 868 By similarity.
DISULFID 874 888 By similarity.
DISULFID 881 897 By similarity.
DISULFID 899 910 By similarity.
DISULFID 916 929 By similarity.
DISULFID 923 938 By similarity.
DISULFID 940 951 By similarity.
DISULFID 976 990
DISULFID 984 1001
DISULFID 1003 1012
Amino Acid Sequence for EGF_HUMAN » Pro-epidermal growth factor
MLLTLIILLP VVSKFSFVSL SAPQHWSCPE GTLAGNGNST CVGPAPFLIF SHGNSIFRID TEGTNYEQLV VDAGVSVIMD FHYNEKRIYW VDLERQLLQR VFLNGSRQER VCNIEKNVSG MAINWINEEV IWSNQQEGII TVTDMKGNNS HILLSALKYP ANVAVDPVER FIFWSSEVAG SLYRADLDGV GVKALLETSE KITAVSLDVL DKRLFWIQYN REGSNSLICS CDYDGGSVHI SKHPTQHNLF AMSLFGDRIF YSTWKMKTIW IANKHTGKDM VRINLHSSFV PLGELKVVHP LAQPKAEDDT WEPEQKLCKL RKGNCSSTVC GQDLQSHLCM CAEGYALSRD RKYCEDVNEC AFWNHGCTLG CKNTPGSYYC TCPVGFVLLP DGKRCHQLVS CPRNVSECSH DCVLTSEGPL CFCPEGSVLE RDGKTCSGCS SPDNGGCSQL CVPLSPVSWE CDCFPGYDLQ LDEKSCAASG PQPFLLFANS QDIRHMHFDG TDYGTLLSQQ MGMVYALDHD PVENKIYFAH TALKWIERAN MDGSQRERLI EEGVDVPEGL AVDWIGRRFY WTDRGKSLIG RSDLNGKRSK IITKENISQP RGIAVHPMAK RLFWTDTGIN PRIESSSLQG LGRLVIASSD LIWPSGITID FLTDKLYWCD AKQSVIEMAN LDGSKRRRLT QNDVGHPFAV AVFEDYVWFS DWAMPSVMRV NKRTGKDRVR LQGSMLKPSS LVVVHPLAKP GADPCLYQNG GCEHICKKRL GTAWCSCREG FMKASDGKTC LALDGHQLLA GGEVDLKNQV TPLDILSKTR VSEDNITESQ HMLVAEIMVS DQDDCAPVGC SMYARCISEG EDATCQCLKG FAGDGKLCSD IDECEMGVPV CPPASSKCIN TEGGYVCRCS EGYQGDGIHC LDIDECQLGE HSCGENASCT NTEGGYTCMC AGRLSEPGLI CPDSTPPPHL REDDHHYSVR NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW ELRHAGHGQQ QKVIVVAVCV VVLVMLLLLS LWGAHYYRTQ KLLSKNPKNP YEESSRDVRS RRPADTEDGM SSCPQPWFVV IKEHQDLKNG GQPVAGEDGQ AADGSMQPTS WRQEPQLCGM GTEQGCWIPV SSDKGSCPQV MERSFHMPSY GTQTLEGGVE KPHSLLSANP LWQQRALDPP HQMELTQ