EFNB3_HUMAN » Ephrin-B3

EFNB3_HUMAN » Ephrin-B3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EFNB3_HUMAN » Ephrin-B3 » EPH-related receptor transmembrane ligand ELK-L3;EPH-related receptor tyrosine kinase ligand 8;LERK-8;
Hydrophobic Thickness 32.8 ± 2.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -24.0 kcal/mol
ΔGfold -12.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 230-252 (224-256)
Pathways

Axon guidance (KEGG)

PDB 4bkf (C/D=27-169)
OPM none
Complexes

EFNB3:EPHA4_HUMAN

Interactions

EPHA4, Complex: EFNB3:EPHA4, PDBID: 4bkf, PubMed

EPHB3, Complex: EPHB3:EFNB3, PubMed

Domains

AA: 28-167, PDBID: 4BKF, Subunit D, Seq Identity:100%, Ephrin

UniProt annotation for EFNB3_HUMAN » Ephrin-B3
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).

SUBUNIT: Interacts with GRIP1 and GRIP2. Binds to Nipah virus G protein.

TISSUE SPECIFICITY: Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.

UniProt features for EFNB3_HUMAN » Ephrin-B3
SIGNAL 1 27
CHAIN 28 340 Ephrin-B3.
DOMAIN 28 167 Ephrin RBD.
MOTIF 338 340 PDZ-binding (Potential).
DISULFID 62 104 By similarity.
DISULFID 92 156 By similarity.
Amino Acid Sequence for EFNB3_HUMAN » Ephrin-B3
MGPPHSGPGG VRVGALLLLG VLGLVSGLSL EPVYWNSANK RFQAEGGYVL YPQIGDRLDL LCPRARPPGP HSSPNYEFYK LYLVGGAQGR RCEAPPAPNL LLTCDRPDLD LRFTIKFQEY SPNLWGHEFR SHHDYYIIAT SDGTREGLES LQGGVCLTRG MKVLLRVGQS PRGGAVPRKP VSEMPMERDR GAAHSLEPGK ENLPGDPTSN ATSRGAEGPL PPPSMPAVAG AAGGLALLLL GVAGAGGAMC WRRRRAKPSE SRHPGPGSFG RGGSLGLGGG GGMGPREAEP GELGIALRGG GAADPPFCPH YEKVSGDYGH PVYIVQDGPP QSPPNIYYKV