EFNB2_HUMAN » Ephrin-B2

EFNB2_HUMAN » Ephrin-B2
Magnify EFNB2_HUMAN » Ephrin-B2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EFNB2_HUMAN » Ephrin-B2 » EPH-related receptor tyrosine kinase ligand 5;LERK-5; HTK ligand;HTK-L;
Hydrophobic Thickness 38.8 ± 3.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -49.7 kcal/mol
ΔGfold -28.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 227-252 (223-256)
Pathways

Axon guidance (KEGG)

PDB 2i85 (25-166), 2vsk (B/D=28-165), 2wo2 (B=27-167), 3gxu (B=27-169), 2hle (B=28-165), 2vsm (B=28-165)
OPM none
Complexes

EFNB2:EPHB2_MOUSE

EFNB2:EPHA4_HUMAN

EPHB4:Q96L35:EFNB2_HUMAN

Interactions

EPHA3, Complex: EFNB2:EPHA3, PubMed

EPHA4, Complex: EFNB2:EPHA4, PDBID: 2wo2

EPHB1, Complex: EFNB2:EPHB1, PubMed

EPHB2, Complex: EFNB2:EPHB2, PDBID: 1kgy

EPHB4, Complex: EFNB2:EPHB4, PDBID: 2hle

EPHB6, Complex: EPHB6:EFNB2, PubMed

PECA1, Complex: EFNB2:PECA1, PubMed

SDC1, Complex: SDC1:EFNB2, PubMed

Domains

AA: 29-164, PDBID: 2HLE, Subunit B, Seq Identity:100%, Ephrin

UniProt annotation for EFNB2_HUMAN » Ephrin-B2
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

SUBUNIT: Interacts with PDZRN3 (By similarity). Binds to the receptor tyrosine kinases EPHA4, EPHB4 and EPHA3. Binds to Hendra virus and Nipah virus G protein.

TISSUE SPECIFICITY: Lung and kidney.

UniProt features for EFNB2_HUMAN » Ephrin-B2
SIGNAL 1 27 Potential.
CHAIN 28 333 Ephrin-B2.
DOMAIN 28 164 Ephrin RBD.
MOTIF 331 333 PDZ-binding (Potential).
DISULFID 62 101
DISULFID 89 153
Amino Acid Sequence for EFNB2_HUMAN » Ephrin-B2
MAVRRDSVWK YCWGVLMVLC RTAISKSIVL EPIYWNSSNS KFLPGQGLVL YPQIGDKLDI ICPKVDSKTV GQYEYYKVYM VDKDQADRCT IKKENTPLLN CAKPDQDIKF TIKFQEFSPN LWGLEFQKNK DYYIISTSNG SLEGLDNQEG GVCQTRAMKI LMKVGQDASS AGSTRNKDPT RRPELEAGTN GRSSTTSPFV KPNPGSSTDG NSAGHSGNNI LGSEVALFAG IASGCIIFIV IIITLVVLLL KYRRRHRKHS PQHTTTLSLS TLATPKRSGN NNGSEPSDII IPLRTADSVF CPHYEKVSGD YGHPVYIVQE MPPQSPANIY YKV