EFNB1_HUMAN » Ephrin-B1

EFNB1_HUMAN » Ephrin-B1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EFNB1_HUMAN » Ephrin-B1 » EFL-3;ELK ligand;ELK-L; EPH-related receptor tyrosine kinase ligand 2;LERK-2;
Hydrophobic Thickness 36.4 ± 5.0 Å
Tilt Angle 27 ± 1°
ΔGtransfer -30.2 kcal/mol
ΔGfold -29.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 237-265 (236-270)
Pathways

Axon guidance (KEGG)

PDB none
OPM none
Complexes none
Interactions

EGFR, Complex: EGFR:EFNB1, PubMed

EPHA2, Complex: EFNB1:EPHA2:TIAM1, PubMed

EPHA3, Complex: EFNB1:EPHA3, PubMed

EPHB1, Complex: EPHB1:EFNB1, PubMed

ERBB2, Complex: EFNB1:ERBB2, PubMed

Domains

AA: 30-164, PDBID: 1IKO, Subunit P, Seq Identity:61%, Ephrin

UniProt annotation for EFNB1_HUMAN » Ephrin-B1
FUNCTION: Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).

FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).

SUBUNIT: Interacts with GRIP1 and GRIP2. Interacts with TLE1.

TISSUE SPECIFICITY: Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas.

INDUCTION: By TNF.

DISEASE: Craniofrontonasal syndrome (CFNS) OMIM: X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies. mutations affecting the gene represented in this entry.

UniProt features for EFNB1_HUMAN » Ephrin-B1
SIGNAL 1 27
CHAIN 28 346 Ephrin-B1.
DOMAIN 30 164 Ephrin RBD.
MOTIF 344 346 PDZ-binding (Potential).
DISULFID 64 101 By similarity.
DISULFID 89 153 By similarity.
Amino Acid Sequence for EFNB1_HUMAN » Ephrin-B1
MARPGQRWLG KWLVAMVVWA LCRLATPLAK NLEPVSWSSL NPKFLSGKGL VIYPKIGDKL DIICPRAEAG RPYEYYKLYL VRPEQAAACS TVLDPNVLVT CNRPEQEIRF TIKFQEFSPN YMGLEFKKHH DYYITSTSNG SLEGLENREG GVCRTRTMKI IMKVGQDPNA VTPEQLTTSR PSKEADNTVK MATQAPGSRG SLGDSDGKHE TVNQEEKSGP GASGGSSGDP DGFFNSKVAL FAAVGAGCVI FLLIIIFLTV LLLKLRKRHR KHTQQRAAAL SLSTLASPKG GSGTAGTEPS DIIIPLRTTE NNYCPHYEKV SGDYGHPVYI VQEMPPQSPA NIYYKV