EFC1_HUMAN » HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein

EFC1_HUMAN » HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
EFC1_HUMAN » HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein » Envelope polyprotein;Fc1env;HERV-Fc1env;
Hydrophobic Thickness 34.8 ± 5.4 Å
Tilt Angle 29 ± 0°
ΔGtransfer -30.2 kcal/mol
ΔGfold -21.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 515-543 (512-546)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 153-549, PDBID: 1XNL, Subunit A, Seq Identity:63%, ENV polyprotein (coat polyprotein)

UniProt annotation for EFC1_HUMAN » HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.

FUNCTION: SU mediates receptor recognition.

FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

SUBUNIT: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

TISSUE SPECIFICITY: Low expression in skin, testis and trachea.

DOMAIN: The CKS-17 immunosuppressive domain is present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo (By similarity).

MISCELLANEOUS: Orthologs in Pan troglodytes and Gorilla gorilla (truncated).

UniProt features for EFC1_HUMAN » HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein
SIGNAL 1 22 Potential.
CHAIN 23 584 HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein.
CHAIN 23 383 Surface protein (By similarity).
CHAIN 384 584 Transmembrane protein (By similarity).
REGION 384 404 Fusion peptide (Potential).
MOTIF 251 254 CXXC (By similarity).
MOTIF 449 465 CKS-17 (By similarity).
MOTIF 466 474 CX6CC (By similarity).
SITE 383 384 Cleavage (By similarity).
DISULFID 466 473 By similarity.
Amino Acid Sequence for EFC1_HUMAN » HERV-F(c)1_Xq21.33 provirus ancestral Env polyprotein
MARPSPLCLL LLLTLLTPIV PSNSLLTEPP FRWRFYLHET WTQGNRLSTV TLATVDCQPH GCQAQVTFNF TSFKSVLRGW SNPTICFVYD QTHSNCRDYW VDTNGGCPYA YCRMHVTQLH TAKKLQHTYR LTSDGRTTYF LTIPDPWDSR WVSGVTGRLY RWPTDSYPVG KLRIFLTYIR VIPQVLSNLK DQADNIKHQE EVINTLVQSH PKADMVTYDD KAEAGPFSWI TLVRHGARLV NMAGLVNLSH CFLCTALSQP PLVAVPLPQA FNTSGNHTAH PSGVFSEQVP LFRDPLQPQF PFCYTTPNSS WCNQTYSGSL SNLSAPAGGY FWCNFTLTKH LNISSNNTLS RNLCLPISLV PRLTLYSEAE LSSLVNPPMR QKRAVFPPLV IGVSLTSSLV ASGLGTGAIV HFISSSQDLS IKLQMAIEAS AESLASLQRQ ITSVAKVAMQ NRRALDLLTA DKGGTCMFLG EECCYYINES GLVETSLLTL DKIRDGLHRP SSTPNYGGGW WQSPLTTWII PFISPILIIC LLLLIAPCVL KFIKNRISEV SRVTVNQMLL HPYSRLPTSE DHYDDALTQQ EAAR