ECSCR_HUMAN » Endothelial cell-specific chemotaxis regulator

ECSCR_HUMAN » Endothelial cell-specific chemotaxis regulator
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ECSCR_HUMAN » Endothelial cell-specific chemotaxis regulator » Endothelial cell-specific molecule 2;
Hydrophobic Thickness 41.2 ± 3.4 Å
Tilt Angle 25 ± 3°
ΔGtransfer -38.7 kcal/mol
ΔGfold -32.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 118-147 (117-154)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 101-203, Endothelial cell-specific chemotaxis regulator

UniProt annotation for ECSCR_HUMAN » Endothelial cell-specific chemotaxis regulator
FUNCTION: Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.

SUBUNIT: Interacts with FLNA. Interacts with the 20S proteasome subunit PSMA7.

TISSUE SPECIFICITY: Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells.

UniProt features for ECSCR_HUMAN » Endothelial cell-specific chemotaxis regulator
SIGNAL 1 24 Potential.
CHAIN 25 205 Endothelial cell-specific chemotaxis regulator.
Amino Acid Sequence for ECSCR_HUMAN » Endothelial cell-specific chemotaxis regulator
MGTAGAMQLC WVILGFLLFR GHNSQPTMTQ TSSSQGGLGG LSLTTEPVSS NPGYIPSSEA NRPSHLSSTG TPGAGVPSSG RDGGTSRDTF QTVPPNSTTM SLSMREDATI LPSPTSETVL TVAAFGVISF IVILVVVVII LVGVVSLRFK CRKSKESEDP QKPGSSGLSE SCSTANGEKD SITLISMKNI NMNNGKQSLS AEKVL