E41L3_HUMAN » Band 4.1-like protein 3

E41L3_HUMAN » Band 4.1-like protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
E41L3_HUMAN » Band 4.1-like protein 3 » 4.1B;Differentially expressed in adenocarcinoma of the lung protein 1;DAL-1;
Hydrophobic Thickness 28.8 ± 2.7 Å
Tilt Angle 19 ± 5°
ΔGtransfer -25.0 kcal/mol
ΔGfold -13.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 632-651 (632-658)
Pathways none
PDB 2he7 (A=108-390), 3bin (A=109-390)
OPM none
Complexes none
Interactions none
Domains

AA: 114-177, PDBID: 2HE7, Subunit A, Seq Identity:100%, FERM N-terminal domain

AA: 192-301, PDBID: 2HE7, Subunit A, Seq Identity:100%, FERM central domain

AA: 305-395, PDBID: 2HE7, Subunit A, Seq Identity:100%, FERM C-terminal PH-like domain

AA: 398-441, FERM adjacent (FA)

AA: 717-765, SAB domain

AA: 973-1079, 4.1 protein C-terminal domain (CTD)

UniProt annotation for E41L3_HUMAN » Band 4.1-like protein 3
FUNCTION: Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5.
UniProt features for E41L3_HUMAN » Band 4.1-like protein 3
CHAIN 1 1087 Band 4.1-like protein 3.

CHAIN 2 1087 Band 4.1-like protein 3, N-terminally processed.

DOMAIN 110 391 FERM.

REGION 394 513 Hydrophilic.

REGION 514 860 Spectrin--actin-binding.

REGION 861 1083 C-terminal (CTD).

Amino Acid Sequence for E41L3_HUMAN » Band 4.1-like protein 3
MTTESGSDSE SKPDQEAEPQ EAAGAQGRAG APVPEPPKEE QQQALEQFAA AAAHSTPVRR EVTDKEQEFA ARAAKQLEYQ QLEDDKLSQK SSSSKLSRSP LKIVKKPKSM QCKVILLDGS EYTCDVEKRS RGQVLFDKVC EHLNLLEKDY FGLTYRDAEN QKNWLDPAKE IKKQVRSGAW HFSFNVKFYP PDPAQLSEDI TRYYLCLQLR DDIVSGRLPC SFVTLALLGS YTVQSELGDY DPDECGSDYI SEFRFAPNHT KELEDKVIEL HKSHRGMTPA EAEMHFLENA KKLSMYGVDL HHAKDSEGVE IMLGVCASGL LIYRDRLRIN RFAWPKVLKI SYKRNNFYIK IRPGEFEQFE STIGFKLPNH RAAKRLWKVC VEHHTFFRLL LPEAPPKKFL TLGSKFRYSG RTQAQTRRAS ALIDRPAPYF ERSSSKRYTM SRSLDGEVGT GQYATTKGIS QTNLITTVTP EKKAEEERDE EEDKRRKGEE VTPISAIRHE GKSPGLGTDS CPLSPPSTHC APTSPTELRR RCKENDCKLP GYEPSRAEHL PGEPALDSDG PGRPYLGDQD VAFSYRQQTG KGTTLFSFSL QLPESFPSLL DDDGYLSFPN LSETNLLPQS LQHYLPIRSP SLVPCFLFIF FFLLSASFSV PYALTLSFPL ALCLCYLEPK AASLSASLDN DPSDSSEEET DSERTDTAAD GETTATESDQ EEDAELKAQE LEKTQDDLMK HQTNISELKR TFLETSTDTA VTNEWEKRLS TSPVRLAARQ EDAPMIEPLV PEETKQSSGE KLMDGSEIFS LLESARKPTE FIGGVTSTSQ SWVQKMETKT ESSGIETEPT VHHLPLSTEK VVQETVLVEE RRVVHASGDA SYSAGDSGDA AAQPAFTGIK GKEGSALTEG AKEEGGEEVA KAVLEQEETA AASRERQEEQ SAAIHISETL EQKPHFESST VKTETISFGS VSPGGVKLEI STKEVPVVHT ETKTITYESS QVDPGTDLEP GVLMSAQTIT SETTSTTTTT HITKTVKGGI SETRIEKRIV ITGDADIDHD QALAQAIKEA KEQHPDMSVT KVVVHKETEI TPEDGED