DYNAP_HUMAN » Dynactin-associated protein

DYNAP_HUMAN » Dynactin-associated protein
Magnify DYNAP_HUMAN » Dynactin-associated proteinEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
DYNAP_HUMAN » Dynactin-associated protein »
Hydrophobic Thickness 40.0 ± 5.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -26.8 kcal/mol
ΔGfold -23.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 110-136 (108-139)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 108-137, CLLAC-motif containing domain

UniProt annotation for DYNAP_HUMAN » Dynactin-associated protein
FUNCTION: Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at "Ser-473".

SUBUNIT: Interacts with DCTN1 and DCTN2.

TISSUE SPECIFICITY: Expressed in fibroblast and numerous cancer cell lines (at protein level).

UniProt features for DYNAP_HUMAN » Dynactin-associated protein
CHAIN 1 210 Dynactin-associated protein.
Amino Acid Sequence for DYNAP_HUMAN » Dynactin-associated protein
MVADIKGNEQ IEKYSWREAC DTGSSRMDRK HGKYILNVEH SENQPPITHP NDQEAHSSIC WCLPSNDITS DVSPNLTGVC VNPGILAHSR CLQSESCNTQ VKEYCRNDWS MWKVFLACLL ACVIMTAIGV LIICLVNNKG SANSSIVIQL STNDGECVTV KPGTPSPACP PTMTTTSTVP ASTATESTTS TATAATTSTE PITVAPTDHL