DSG2_HUMAN » Desmoglein-2

DSG2_HUMAN » Desmoglein-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DSG2_HUMAN » Desmoglein-2 » Cadherin family member 5;HDGC;
Hydrophobic Thickness 34.8 ± 4.6 Å
Tilt Angle 1 ± 1°
ΔGtransfer -47.6 kcal/mol
ΔGfold -27.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 612-637 (612-642)
Pathways

Apoptosis (Reactome)

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

PDB 2yqg (47-162)
OPM none
Complexes none
Interactions

DSC1, Complex: DSC1:DSG2, PubMed

DSC2, Complex: DSG2:DSC2, PubMed

EGFR, Complex: DSG2:EGFR

NICA, Complex: DSG2:NICA, PubMed

NICA, Complex: DSG2:PSN1:NICA, PubMed

RYK, Complex: RYK:DSG2, PubMed

Domains

AA: 164-263, PDBID: 1EDH, Subunit B, Seq Identity:41%, Cadherin domain

AA: 278-378, PDBID: 3Q2W, Subunit A, Seq Identity:28%, Cadherin domain

AA: 396-490, PDBID: 3Q2W, Subunit A, Seq Identity:30%, Cadherin domain

UniProt annotation for DSG2_HUMAN » Desmoglein-2
FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

TISSUE SPECIFICITY: All of the tissues tested and carcinomas.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

DISEASE: Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10) OMIM: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. mutations affecting the gene represented in this entry.

DISEASE: Cardiomyopathy, dilated 1BB (CMD1BB) OMIM: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. associated with variations affecting the gene represented in this entry.

UniProt features for DSG2_HUMAN » Desmoglein-2
SIGNAL 1 23 Potential.
PROPEP 24 49 Potential.
CHAIN 50 1118 Desmoglein-2.
DOMAIN 50 160 Cadherin 1.
DOMAIN 161 273 Cadherin 2.
DOMAIN 274 388 Cadherin 3.
DOMAIN 389 503 Cadherin 4.
REPEAT 881 912 Desmoglein repeat 1.
REPEAT 913 942 Desmoglein repeat 2.
REPEAT 943 968 Desmoglein repeat 3.
REPEAT 969 992 Desmoglein repeat 4.
REPEAT 993 1021 Desmoglein repeat 5.
REPEAT 1022 1051 Desmoglein repeat 6.
Amino Acid Sequence for DSG2_HUMAN » Desmoglein-2
MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA WITAPVALRE GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG IFVFNKDTGE LNVTSILDRE ETPFFLLTGY ALDARGNNVE KPLELRIKVL DINDNEPVFT QDVFVGSVEE LSAAHTLVMK INATDADEPN TLNSKISYRI VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE ARDGNGEVTD KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF SVIVANKAAF HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES MDRSSKGQII GNFQAFDEDT GLPAHARYVK LEDRDNWISV DSVTSEIKLA KLPDFESRYV QNGTYTVKIV AISEDYPRKT ITGTVLINVE DINDNCPTLI EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM AEKWKIARQE STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT IEMLHPWNNE GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS SASIVKGQHE MSEMDGRWEE HRSLLSGRAT QFTGATGAIM TTETTKTARA TGASRDMAGA QAAAVALNEE FLRNYFTDKA ASYTEEDENH TAKDCLLVYS QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC LGQKIDINKE IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT VILGPSQPQS LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN PLEGTQHLQD VPYVMVRERE SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV LAPASTLQSS YQIPTENSMT ARNTTVSGAG VPGPLPDFGL EESGHSNSTI TTSSTRVTKH STVQHSYS