DSG1_HUMAN » Desmoglein-1

DSG1_HUMAN » Desmoglein-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DSG1_HUMAN » Desmoglein-1 » Cadherin family member 4;Desmosomal glycoprotein 1;DG1; DGI; Pemphigus foliaceus antigen;
Hydrophobic Thickness 34.2 ± 1.2 Å
Tilt Angle 3 ± 3°
ΔGtransfer -23.2 kcal/mol
ΔGfold -12.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 548-570 (548-570)
Pathways

Apoptosis (Reactome)

Staphylococcus aureus infection (KEGG)

PDB none
OPM none
Complexes none
Interactions

DSC1, Complex: DSC1:DSG1, PubMed

DSC2, Complex: DSG1:DSC2, PubMed

ESR1, Complex: DSG1:ESR1, PubMed

Domains

AA: 54-148, PDBID: 1EDH, Subunit B, Seq Identity:35%, Cadherin domain

AA: 162-260, PDBID: 2O72, Subunit A, Seq Identity:39%, Cadherin domain

AA: 274-377, PDBID: 4ZPS, Subunit A, Seq Identity:27%, Cadherin domain

AA: 641-765, PDBID: 1I7W, Subunit B, Seq Identity:22%, Cadherin cytoplasmic region

UniProt annotation for DSG1_HUMAN » Desmoglein-1
FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

SUBUNIT: Binds to JUP/plakoglobin.

TISSUE SPECIFICITY: Epidermis, tongue, tonsil and esophagus.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

DISEASE: Palmoplantar keratoderma 1, striate, focal, or diffuse (PPKS1) OMIM: A dermatological disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. by mutations affecting the gene represented in this entry.

DISEASE: Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE (EPKHE) OMIM: A syndrome characterized by severe dermatitis, multiple allergies and metabolic wasting. Clinical features include erythroderma, yellowish papules and plaques arranged at the periphery of the palms, along the fingers and over weight-bearing areas of the feet, skin erosions and scaling, and hypotrichosis. Additionally, patients manifest severe food allergies, elevated immunoglobulin E (IgE) levels and recurrent infections with marked metabolic wasting. by mutations affecting the gene represented in this entry.

UniProt features for DSG1_HUMAN » Desmoglein-1
SIGNAL 1 23 Potential.
PROPEP 24 49 Potential.
CHAIN 50 1049 Desmoglein-1.
DOMAIN 50 158 Cadherin 1.
DOMAIN 159 270 Cadherin 2.
DOMAIN 271 385 Cadherin 3.
DOMAIN 386 497 Cadherin 4.
REPEAT 813 839 Desmoglein repeat 1.
REPEAT 840 869 Desmoglein repeat 2.
REPEAT 870 899 Desmoglein repeat 3.
REPEAT 900 927 Desmoglein repeat 4.
REPEAT 928 956 Desmoglein repeat 5.
Amino Acid Sequence for DSG1_HUMAN » Desmoglein-1
MDWSFFRVVA VLFIFLVVVE VNSEFRIQVR DYNTKNGTIK WHSIRRQKRE WIKFAAACRE GEDNSKRNPI AKIHSDCAAN QQVTYRISGV GIDQPPYGIF VINQKTGEIN ITSIVDREVT PFFIIYCRAL NSMGQDLERP LELRVRVLDI NDNPPVFSMA TFAGQIEENS NANTLVMILN ATDADEPNNL NSKIAFKIIR QEPSDSPMFI INRNTGEIRT MNNFLDREQY GQYALAVRGS DRDGGADGMS AECECNIKIL DVNDNIPYME QSSYTIEIQE NTLNSNLLEI RVIDLDEEFS ANWMAVIFFI SGNEGNWFEI EMNERTNVGI LKVVKPLDYE AMQSLQLSIG VRNKAEFHHS IMSQYKLKAS AISVTVLNVI EGPVFRPGSK TYVVTGNMGS NDKVGDFVAT DLDTGRPSTT VRYVMGNNPA DLLAVDSRTG KLTLKNKVTK EQYNMLGGKY QGTILSIDDN LQRTCTGTIN INIQSFGNDD RTNTEPNTKI TTNTGRQEST SSTNYDTSTT STDSSQVYSS EPGNGAKDLL SDNVHFGPAG IGLLIMGFLV LGLVPFLMIC CDCGGAPRSA AGFEPVPECS DGAIHSWAVE GPQPEPRDIT TVIPQIPPDN ANIIECIDNS GVYTNEYGGR EMQDLGGGER MTGFELTEGV KTSGMPEICQ EYSGTLRRNS MRECREGGLN MNFMESYFCQ KAYAYADEDE GRPSNDCLLI YDIEGVGSPA GSVGCCSFIG EDLDDSFLDT LGPKFKKLAD ISLGKESYPD LDPSWPPQST EPVCLPQETE PVVSGHPPIS PHFGTTTVIS ESTYPSGPGV LHPKPILDPL GYGNVTVTES YTTSDTLKPS VHVHDNRPAS NVVVTERVVG PISGADLHGM LEMPDLRDGS NVIVTERVIA PSSSLPTSLT IHHPRESSNV VVTERVIQPT SGMIGSLSMH PELANAHNVI VTERVVSGAG VTGISGTTGI SGGIGSSGLV GTSMGAGSGA LSGAGISGGG IGLSSLGGTA SIGHMRSSSD HHFNQTIGSA SPSTARSRIT KYSTVQYSK