DSC3_HUMAN » Desmocollin-3

DSC3_HUMAN » Desmocollin-3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DSC3_HUMAN » Desmocollin-3 » Cadherin family member 3;Desmocollin-4;HT-CP;
Hydrophobic Thickness 42.0 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -58.0 kcal/mol
ΔGfold -24.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 690-718 (690-721)
Pathways none
PDB none
OPM none
Complexes none
Interactions

RYK, Complex: DSC3:RYK, PubMed

Domains

AA: 27-113, PDBID: 1OP4, Subunit A, Seq Identity:24%, Cadherin prodomain like

AA: 140-234, PDBID: 1EDH, Subunit B, Seq Identity:38%, Cadherin domain

AA: 248-346, PDBID: 1NCJ, Subunit A, Seq Identity:42%, Cadherin domain

AA: 360-463, PDBID: 3Q2V, Subunit A, Seq Identity:27%, Cadherin domain

AA: 476-568, PDBID: 3Q2W, Subunit A, Seq Identity:39%, Cadherin domain

AA: 787-896, PDBID: 2KOH, Subunit B, Seq Identity:16%, Cadherin cytoplasmic region

UniProt annotation for DSC3_HUMAN » Desmocollin-3
FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

TISSUE SPECIFICITY: Epidermis, buccal mucosa, esophagus and cervix.

DOMAIN: Calcium may be bound by the cadherin-like repeats.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

DISEASE: Hypotrichosis and recurrent skin vesicles (HRSV) OMIM: A disorder characterized by hypotrichosis and the appearance of recurrent skin vesicle formation. Affected individuals show sparse and fragile hair on scalp, as well as absent eyebrows and eyelashes. Vesicles filled with thin, watery fluid are observed on the scalp and skin of most of the body. Mucosal vesicles are absent. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for DSC3_HUMAN » Desmocollin-3
SIGNAL 1 27 Potential.
PROPEP 28 135 Potential.
CHAIN 136 896 Desmocollin-3.
DOMAIN 136 243 Cadherin 1.
DOMAIN 244 355 Cadherin 2.
DOMAIN 356 471 Cadherin 3.
DOMAIN 472 579 Cadherin 4.
DOMAIN 580 690 Cadherin 5.
Amino Acid Sequence for DSC3_HUMAN » Desmocollin-3
MAAAGPRRSV RGAVCLHLLL TLVIFSRAGE ACKKVILNVP SKLEADKIIG RVNLEECFRS ADLIRSSDPD FRVLNDGSVY TARAVALSDK KRSFTIWLSD KRKQTQKEVT VLLEHQKKVS KTRHTRETVL RRAKRRWAPI PCSMQENSLG PFPLFLQQVE SDAAQNYTVF YSISGRGVDK EPLNLFYIER DTGNLFCTRP VDREEYDVFD LIAYASTADG YSADLPLPLP IRVEDENDNH PVFTEAIYNF EVLESSRPGT TVGVVCATDR DEPDTMHTRL KYSILQQTPR SPGLFSVHPS TGVITTVSHY LDREVVDKYS LIMKVQDMDG QFFGLIGTST CIITVTDSND NAPTFRQNAY EAFVEENAFN VEILRIPIED KDLINTANWR VNFTILKGNE NGHFKISTDK ETNEGVLSVV KPLNYEENRQ VNLEIGVNNE APFARDIPRV TALNRALVTV HVRDLDEGPE CTPAAQYVRI KENLAVGSKI NGYKAYDPEN RNGNGLRYKK LHDPKGWITI DEISGSIITS KILDREVETP KNELYNITVL AIDKDDRSCT GTLAVNIEDV NDNPPEILQE YVVICKPKMG YTDILAVDPD EPVHGAPFYF SLPNTSPEIS RLWSLTKVND TAARLSYQKN AGFQEYTIPI TVKDRAGQAA TKLLRVNLCE CTHPTQCRAT SRSTGVILGK WAILAILLGI ALLFSVLLTL VCGVFGATKG KRFPEDLAQQ NLIISNTEAP GDDRVCSANG FMTQTTNNSS QGFCGTMGSG MKNGGQETIE MMKGGNQTLE SCRGAGHHHT LDSCRGGHTE VDNCRYTYSE WHSFTQPRLG EKLHRCNQNE DRMPSQDYVL TYNYEGRGSP AGSVGCCSEK QEEDGLDFLN NLEPKFITLA EACTKR