DSC2_HUMAN » Desmocollin-2

DSC2_HUMAN » Desmocollin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DSC2_HUMAN » Desmocollin-2 » Cadherin family member 2;Desmocollin-3;Desmosomal glycoprotein II;Desmosomal glycoprotein III;
Hydrophobic Thickness 31.6 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.5 kcal/mol
ΔGfold -23.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 694-716 (694-719)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

PDB none
OPM none
Complexes none
Interactions

DSG1, Complex: DSG1:DSC2, PubMed

DSG2, Complex: DSG2:DSC2, PubMed

RYK, Complex: RYK:DSC2, PubMed

Domains

AA: 30-113, PDBID: 1OP4, Subunit A, Seq Identity:25%, Cadherin prodomain like

AA: 140-234, PDBID: 4OY9, Subunit A, Seq Identity:40%, Cadherin domain

AA: 248-346, PDBID: 3K5S, Subunit B, Seq Identity:40%, Cadherin domain

AA: 360-463, PDBID: 3Q2V, Subunit A, Seq Identity:41%, Cadherin domain

AA: 476-568, PDBID: 3Q2W, Subunit A, Seq Identity:42%, Cadherin domain

AA: 792-901, PDBID: 4R10, Subunit B, Seq Identity:16%, Cadherin cytoplasmic region

UniProt annotation for DSC2_HUMAN » Desmocollin-2
FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

SUBUNIT: Interacts with DSP, PKP2 and JUP.

TISSUE SPECIFICITY: Expressed in epithelia, myocardium and lymph nodes.

DOMAIN: Calcium may be bound by the cadherin-like repeats.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

DISEASE: Arrhythmogenic right ventricular dysplasia, familial, 11 (ARVD11) OMIM: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for DSC2_HUMAN » Desmocollin-2
SIGNAL 1 27 Potential.
PROPEP 28 135 Potential.
CHAIN 136 901 Desmocollin-2.
DOMAIN 136 243 Cadherin 1.
DOMAIN 244 355 Cadherin 2.
DOMAIN 356 471 Cadherin 3.
DOMAIN 472 579 Cadherin 4.
DOMAIN 580 694 Cadherin 5.
Amino Acid Sequence for DSC2_HUMAN » Desmocollin-2
MEAARPSGSW NGALCRLLLL TLAILIFASD ACKNVTLHVP SKLDAEKLVG RVNLKECFTA ANLIHSSDPD FQILEDGSVY TTNTILLSSE KRSFTILLSN TENQEKKKIF VFLEHQTKVL KKRHTKEKVL RRAKRRWAPI PCSMLENSLG PFPLFLQQVQ SDTAQNYTIY YSIRGPGVDQ EPRNLFYVER DTGNLYCTRP VDREQYESFE IIAFATTPDG YTPELPLPLI IKIEDENDNY PIFTEETYTF TIFENCRVGT TVGQVCATDK DEPDTMHTRL KYSIIGQVPP SPTLFSMHPT TGVITTTSSQ LDRELIDKYQ LKIKVQDMDG QYFGLQTTST CIINIDDVND HLPTFTRTSY VTSVEENTVD VEILRVTVED KDLVNTANWR ANYTILKGNE NGNFKIVTDA KTNEGVLCVV KPLNYEEKQQ MILQIGVVNE APFSREASPR SAMSTATVTV NVEDQDEGPE CNPPIQTVRM KENAEVGTTS NGYKAYDPET RSSSGIRYKK LTDPTGWVTI DENTGSIKVF RSLDREAETI KNGIYNITVL ASDQGGRTCT GTLGIILQDV NDNSPFIPKK TVIICKPTMS SAEIVAVDPD EPIHGPPFDF SLESSTSEVQ RMWRLKAIND TAARLSYQND PPFGSYVVPI TVRDRLGMSS VTSLDVTLCD CITENDCTHR VDPRIGGGGV QLGKWAILAI LLGIALLFCI LFTLVCGASG TSKQPKVIPD DLAQQNLIVS NTEAPGDDKV YSANGFTTQT VGASAQGVCG TVGSGIKNGG QETIEMVKGG HQTSESCRGA GHHHTLDSCR GGHTEVDNCR YTYSEWHSFT QPRLGEKVYL CNQDENHKHA QDYVLTYNYE GRGSVAGSVG CCSERQEEDG LEFLDNLEPK FRTLAEACMK R