DSC1_HUMAN » Desmocollin-1

DSC1_HUMAN » Desmocollin-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DSC1_HUMAN » Desmocollin-1 » Cadherin family member 1;Desmosomal glycoprotein 2/3;DG2/DG3;
Hydrophobic Thickness 31.6 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -45.6 kcal/mol
ΔGfold -19.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 691-714 (691-718)
Pathways none
PDB none
OPM none
Complexes none
Interactions

DSG1, Complex: DSC1:DSG1, PubMed

DSG2, Complex: DSC1:DSG2, PubMed

GOSR1, Complex: GOSR1:DSC1, PubMed

Domains

AA: 27-111, PDBID: 1OP4, Subunit A, Seq Identity:20%, Cadherin prodomain like

AA: 139-233, PDBID: 4NQQ, Subunit D, Seq Identity:41%, Cadherin domain

AA: 247-345, PDBID: 1NCJ, Subunit A, Seq Identity:42%, Cadherin domain

AA: 359-463, PDBID: 3Q2W, Subunit A, Seq Identity:42%, Cadherin domain

AA: 476-568, PDBID: 3Q2W, Subunit A, Seq Identity:40%, Cadherin domain

AA: 715-894, PDBID: 4R10, Subunit B, Seq Identity:20%, Cadherin cytoplasmic region

UniProt annotation for DSC1_HUMAN » Desmocollin-1
FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.

SUBUNIT: Binds to JUP/plakoglobin.

TISSUE SPECIFICITY: Strongly expressed in epidermis, less in lymph node and tongue.

DOMAIN: Calcium may be bound by the cadherin-like repeats.

DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

UniProt features for DSC1_HUMAN » Desmocollin-1
SIGNAL 1 29 Potential.
PROPEP 30 134 Potential.
CHAIN 135 894 Desmocollin-1.
DOMAIN 135 242 Cadherin 1.
DOMAIN 243 354 Cadherin 2.
DOMAIN 355 471 Cadherin 3.
DOMAIN 472 575 Cadherin 4.
DOMAIN 576 682 Cadherin 5.
Amino Acid Sequence for DSC1_HUMAN » Desmocollin-1
MALASAAPGS IFCKQLLFSL LVLTLLCDAC QKVYLRVPSH LQAETLVGKV NLEECLKSAS LIRSSDPAFR ILEDGSIYTT HDLILSSERK SFSIFLSDGQ RREQQEIKVV LSARENKSPK KRHTKDTALK RSKRRWAPIP ASLMENSLGP FPQHVQQIQS DAAQNYTIFY SISGPGVDKE PFNLFYIEKD TGDIFCTRSI DREKYEQFAL YGYATTADGY APEYPLPLII KIEDDNDNAP YFEHRVTIFT VPENCRSGTS VGKVTATDLD EPDTLHTRLK YKILQQIPDH PKHFSIHPDT GVITTTTPFL DREKCDTYQL IMEVRDMGGQ PFGLFNTGTI TISLEDENDN PPSFTETSYV TEVEENRIDV EILRMKVQDQ DLPNTPHSKA VYKILQGNEN GNFIISTDPN TNEGVLCVVK PLNYEVNRQV ILQVGVINEA QFSKAASSQT PTMCTTTVTV KIIDSDEGPE CHPPVKVIQS QDGFPAGQEL LGYKALDPEI SSGEGLRYQK LGDEDNWFEI NQHTGDLRTL KVLDRESKFV KNNQYNISVV AVDAVGRSCT GTLVVHLDDY NDHAPQIDKE VTICQNNEDF AVLKPVDPDG PENGPPFQFF LDNSASKNWN IEEKDGKTAI LRQRQNLDYN YYSVPIQIKD RHGLVATHML TVRVCDCSTP SECRMKDKST RDVRPNVILG RWAILAMVLG SVLLLCILFT CFCVTAKRTV KKCFPEDIAQ QNLIVSNTEG PGEEVTEANI RLPMQTSNIC DTSMSVGTVG GQGIKTQQSF EMVKGGYTLD SNKGGGHQTL ESVKGVGQGD TGRYAYTDWQ SFTQPRLGEK VYLCGQDEEH KHCEDYVCSY NYEGKGSLAG SVGCCSDRQE EEGLEFLDHL EPKFRTLAKT CIKK