DOB_HUMAN » HLA class II histocompatibility antigen, DO beta chain

DOB_HUMAN » HLA class II histocompatibility antigen, DO beta chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DOB_HUMAN » HLA class II histocompatibility antigen, DO beta chain » MHC class II antigen DOB;
Hydrophobic Thickness 33.6 ± 2.0 Å
Tilt Angle 1 ± 0°
ΔGtransfer -46.6 kcal/mol
ΔGfold -25.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 222-247 (219-251)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Asthma (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Influenza A (KEGG)

Intestinal immune network for IgA production (KEGG)

Leishmaniasis (KEGG)

Phagosome (KEGG)

Rheumatoid arthritis (KEGG)

Staphylococcus aureus infection (KEGG)

Systemic lupus erythematosus (KEGG)

Toxoplasmosis (KEGG)

Tuberculosis (KEGG)

Type I diabetes mellitus (KEGG)

Viral myocarditis (KEGG)

PDB 4i0p (D/H=30-218)
OPM none
Complexes

DOA:DOB:DMB:Q6ICR9_HUMAN

Interactions

DMB, Complex: DOA:DOB:DMB, PDBID: 4I0P, PubMed

Domains

AA: 39-113, PDBID: 4I0P, Subunit H, Seq Identity:100%, Class II histocompatibility antigen, beta domain

AA: 123-206, PDBID: 4I0P, Subunit H, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for DOB_HUMAN » HLA class II histocompatibility antigen, DO beta chain
FUNCTION: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

SUBUNIT: Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

UniProt features for DOB_HUMAN » HLA class II histocompatibility antigen, DO beta chain
SIGNAL 1 26
CHAIN 27 273 HLA class II histocompatibility antigen, DO beta chain.
DOMAIN 123 213 Ig-like C1-type.
REGION 27 120 Beta-1.
REGION 121 214 Beta-2.
REGION 215 224 Connecting peptide.
DISULFID 41 105 By similarity.
DISULFID 143 199 By similarity.
Amino Acid Sequence for DOB_HUMAN » HLA class II histocompatibility antigen, DO beta chain
MGSGWVPWVV ALLVNLTRLD SSMTQGTDSP EDFVIQAKAD CYFTNGTEKV QFVVRFIFNL EEYVRFDSDV GMFVALTKLG QPDAEQWNSR LDLLERSRQA VDGVCRHNYR LGAPFTVGRK VQPEVTVYPE RTPLLHQHNL LHCSVTGFYP GDIKIKWFLN GQEERAGVMS TGPIRNGDWT FQTVVMLEMT PELGHVYTCL VDHSSLLSPV SVEWRAQSEY SWRKMLSGIA AFLLGLIFLL VGIVIQLRAQ KGYVRTQMSG NEVSRAVLLP QSC