DOA_HUMAN » HLA class II histocompatibility antigen, DO alpha chain

DOA_HUMAN » HLA class II histocompatibility antigen, DO alpha chain
Magnify DOA_HUMAN » HLA class II histocompatibility antigen, DO alpha chainEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
DOA_HUMAN » HLA class II histocompatibility antigen, DO alpha chain » MHC DN-alpha;MHC DZ alpha;MHC class II antigen DOA;
Hydrophobic Thickness 40.4 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -54.4 kcal/mol
ΔGfold -21.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 215-243 (215-248)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Asthma (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Influenza A (KEGG)

Intestinal immune network for IgA production (KEGG)

Leishmaniasis (KEGG)

Phagosome (KEGG)

Rheumatoid arthritis (KEGG)

Staphylococcus aureus infection (KEGG)

Systemic lupus erythematosus (KEGG)

Toxoplasmosis (KEGG)

Tuberculosis (KEGG)

Type I diabetes mellitus (KEGG)

Viral myocarditis (KEGG)

PDB 4i0p (C/G=27-207)
OPM none
Complexes

DOA:DOB:DMB:Q6ICR9_HUMAN

Interactions

DMA, Complex: DMA:DOA, PubMed

DMB, Complex: DOA:DOB:DMB:Q6ICR9, PDBID: 4I0P

DOB, Complex: DOB:DOA, PubMed

Domains

AA: 29-109, PDBID: 4I0P, Subunit G, Seq Identity:100%, Class II histocompatibility antigen, alpha domain

AA: 113-196, PDBID: 4I0P, Subunit C, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 202-250, PDBID: 4I0P, Subunit C, Seq Identity:100%, C1-set C-terminal domain

UniProt annotation for DOA_HUMAN » HLA class II histocompatibility antigen, DO alpha chain
FUNCTION: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

SUBUNIT: Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

UniProt features for DOA_HUMAN » HLA class II histocompatibility antigen, DO alpha chain
SIGNAL 1 25 Potential.
CHAIN 26 250 HLA class II histocompatibility antigen, DO alpha chain.
DOMAIN 113 205 Ig-like C1-type.
REGION 26 110 Alpha-1.
REGION 111 204 Alpha-2.
REGION 205 217 Connecting peptide.
DISULFID 133 189 By similarity.
Amino Acid Sequence for DOA_HUMAN » HLA class II histocompatibility antigen, DO alpha chain
MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH EFDEEQLFSV DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV ERSNRSRAIN VPPRVTVLPK SRVELGQPNI LICIVDNIFP PVINITWLRN GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV PSAEDVYDCQ VEHWGLDAPL LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII MGTYVSSVPR