DNER_HUMAN » Delta and Notch-like epidermal growth factor-related receptor

DNER_HUMAN » Delta and Notch-like epidermal growth factor-related receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DNER_HUMAN » Delta and Notch-like epidermal growth factor-related receptor »
Hydrophobic Thickness 34.8 ± 1.3 Å
Tilt Angle 0 ± 16°
ΔGtransfer -28.3 kcal/mol
ΔGfold -25.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 640-662 (636-667)
Pathways

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

NICA, Complex: DNER:NICA, PubMed

NICA, Complex: NICA:PSN1:DNER, PubMed

Domains

AA: 98-131, PDBID: 3H5C, Subunit B, Seq Identity:47%, EGF-like domain

AA: 353-388, PDBID: 1TOZ, Subunit A, Seq Identity:44%, EGF-like domain

AA: 396-426, PDBID: 1TPG, Subunit A, Seq Identity:48%, EGF-like domain

AA: 434-464, PDBID: 1TOZ, Subunit A, Seq Identity:52%, EGF-like domain

AA: 472-501, PDBID: 1BF9, Subunit A, Seq Identity:47%, EGF-like domain

AA: 509-539, PDBID: 1TOZ, Subunit A, Seq Identity:50%, EGF-like domain

AA: 552-573, PDBID: 2YGQ, Subunit A, Seq Identity:54%, Human growth factor-like EGF

AA: 585-615, PDBID: 1EDM, Subunit B, Seq Identity:60%, EGF-like domain

UniProt annotation for DNER_HUMAN » Delta and Notch-like epidermal growth factor-related receptor
FUNCTION: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

SUBUNIT: Interacts with AP1G1. Interacts with NOTCH1 (By similarity).

TISSUE SPECIFICITY: Expressed in brain, spinal cord and adrenal gland.

UniProt features for DNER_HUMAN » Delta and Notch-like epidermal growth factor-related receptor
SIGNAL 1 34 Potential.
CHAIN 35 737 Delta and Notch-like epidermal growth factor-related receptor.
DOMAIN 44 92 EGF-like 1.
DOMAIN 94 133 EGF-like 2.
DOMAIN 309 348 EGF-like 3.
DOMAIN 349 390 EGF-like 4.
DOMAIN 392 428 EGF-like 5.
DOMAIN 430 466 EGF-like 6.
DOMAIN 468 503 EGF-like 7.
DOMAIN 505 541 EGF-like 8; calcium-binding (Potential).
DOMAIN 543 579 EGF-like 9.
DOMAIN 546 568 Follistatin-like.
DOMAIN 581 617 EGF-like 10; calcium-binding (Potential).
REGION 44 133 Interaction with NOTCH1 (By similarity).
REGION 677 680 Interaction with AP1G1 and somatodendritic targeting (By similarity).
DISULFID 48 59 By similarity.
DISULFID 53 80 By similarity.
DISULFID 82 91 By similarity.
DISULFID 98 108 By similarity.
DISULFID 103 121 By similarity.
DISULFID 123 132 By similarity.
DISULFID 319 336 By similarity.
DISULFID 338 347 By similarity.
DISULFID 353 364 By similarity.
DISULFID 358 378 By similarity.
DISULFID 380 389 By similarity.
DISULFID 396 407 By similarity.
DISULFID 401 416 By similarity.
DISULFID 418 427 By similarity.
DISULFID 434 445 By similarity.
DISULFID 439 454 By similarity.
DISULFID 456 465 By similarity.
DISULFID 472 482 By similarity.
DISULFID 477 491 By similarity.
DISULFID 493 502 By similarity.
DISULFID 509 520 By similarity.
DISULFID 514 529 By similarity.
DISULFID 531 540 By similarity.
DISULFID 547 558 By similarity.
DISULFID 552 567 By similarity.
DISULFID 569 578 By similarity.
DISULFID 585 596 By similarity.
DISULFID 590 605 By similarity.
DISULFID 607 616 By similarity.
Amino Acid Sequence for DNER_HUMAN » Delta and Notch-like epidermal growth factor-related receptor
MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA QPCRNGGVCT SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS NPCHHGNCSS SSSSSSDGYL CICNEGYEGP NCEQALPSLP ATGWTESMAP RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVIPDI ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW KVTATGFQQC SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY DACQRKPCQN NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP CRNGATCISS LSGFTCQCPE GYFGSACEEK VDPCASSPCQ NNGTCYVDGV HFTCNCSPGF TGPTCAQLID FCALSPCAHG TCRSVGTSYK CLCDPGYHGL YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC ELYKDPCANV SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA RFGKKSRPAM YDVSPIAYED YSPDDKPLVT LIKTKDL