DMB_HUMAN » HLA class II histocompatibility antigen, DM beta chain

DMB_HUMAN » HLA class II histocompatibility antigen, DM beta chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DMB_HUMAN » HLA class II histocompatibility antigen, DM beta chain » MHC class II antigen DMB;Really interesting new gene 7 protein;
Hydrophobic Thickness 34.0 ± 3.4 Å
Tilt Angle 36 ± 8°
ΔGtransfer -21.0 kcal/mol
ΔGfold -14.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 213-238 (213-243)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Asthma (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Influenza A (KEGG)

Intestinal immune network for IgA production (KEGG)

Leishmaniasis (KEGG)

Phagosome (KEGG)

Rheumatoid arthritis (KEGG)

Staphylococcus aureus infection (KEGG)

Systemic lupus erythematosus (KEGG)

Toxoplasmosis (KEGG)

Tuberculosis (KEGG)

Type I diabetes mellitus (KEGG)

Viral myocarditis (KEGG)

PDB 2bc4 (B/D=19-256), 4i0p (B/F=21-211), 1hdm (B=19-218), 4fqx (D=19-211), 4gbx (D=19-211)
OPM 2bc4
Complexes

DOA:DOB:DMB:Q6ICR9_HUMAN

DMA:DMB_HUMAN

DMA:DMB:DRA:2B11_HUMAN

Interactions

2B11, Complex: DMA:DMB:DRA:2B11, PDBID: 4FQX

2B14, Complex: 2B14:DMB, PubMed

DMA, Complex: DMA:DMB, PDBID: 1hdm, PubMed

DOB, Complex: DOA:DOB:DMB, PDBID: 4I0P, PubMed

DRA, Complex: DRA:DMB, PubMed

HG2A, Complex: DMB:HG2A, PubMed

Domains

AA: 27-106, PDBID: 1HDM, Subunit B, Seq Identity:100%, Class II histocompatibility antigen, beta domain

AA: 115-199, PDBID: 1HDM, Subunit B, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for DMB_HUMAN » HLA class II histocompatibility antigen, DM beta chain
FUNCTION: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.

SUBUNIT: Heterodimer of an alpha chain (DMA) and a beta chain (DMB).

DOMAIN: The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.

UniProt features for DMB_HUMAN » HLA class II histocompatibility antigen, DM beta chain
SIGNAL 1 18 Potential.
CHAIN 19 263 HLA class II histocompatibility antigen, DM beta chain.
DOMAIN 114 208 Ig-like C1-type.
REGION 19 112 Beta-1.
REGION 113 207 Beta-2.
REGION 208 218 Connecting peptide (Potential).
MOTIF 248 251 YXXZ motif.
DISULFID 29 97
DISULFID 135 192
Amino Acid Sequence for DMB_HUMAN » HLA class II histocompatibility antigen, DM beta chain
MITFLPLLLG LSLGCTGAGG FVAHVESTCL LDDAGTPKDF TYCISFNKDL LTCWDPEENK MAPCEFGVLN SLANVLSQHL NQKDTLMQRL RNGLQNCATH TQPFWGSLTN RTRPPSVQVA KTTPFNTREP VMLACYVWGF YPAEVTITWR KNGKLVMPHS SAHKTAQPNG DWTYQTLSHL ALTPSYGDTY TCVVEHIGAP EPILRDWTPG LSPMQTLKVS VSAVTLGLGL IIFSLGVISW RRAGHSSYTP LPGSNYSEGW HIS