DMA_HUMAN » HLA class II histocompatibility antigen, DM alpha chain

DMA_HUMAN » HLA class II histocompatibility antigen, DM alpha chain
Magnify DMA_HUMAN » HLA class II histocompatibility antigen, DM alpha chainEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DMA_HUMAN » HLA class II histocompatibility antigen, DM alpha chain » MHC class II antigen DMA;Really interesting new gene 6 protein;
Hydrophobic Thickness 34.8 ± 0.6 Å
Tilt Angle 2 ± 0°
ΔGtransfer -43.2 kcal/mol
ΔGfold -15.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 228-256 (228-256)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Asthma (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Influenza A (KEGG)

Intestinal immune network for IgA production (KEGG)

Leishmaniasis (KEGG)

Phagosome (KEGG)

Rheumatoid arthritis (KEGG)

Staphylococcus aureus infection (KEGG)

Systemic lupus erythematosus (KEGG)

Toxoplasmosis (KEGG)

Tuberculosis (KEGG)

Type I diabetes mellitus (KEGG)

Viral myocarditis (KEGG)

PDB 2bc4 (A/C=27-229), 1hdm (A=27-230), 4fqx (C=27-225), 4gbx (C=27-225)
OPM 2bc4
Complexes

DMA:DMB_HUMAN

DMA:DMB:DRA:2B11_HUMAN

Interactions

2B11, Complex: DMA:DMB:DRA:2B11, PDBID: 4FQX

2B13, Complex: 2B13.2B1F.2B1G:DMA.Q31604, PubMed

2B14, Complex: 2B14:DMA, PubMed

2B1F, Complex: 2B1F:DMA, PubMed

B3GA1, Complex: DMA:B3GA1, PubMed

DMB, Complex: DMA:DMB, PDBID: 1HDM, PubMed

DOA, Complex: DMA:DOA, PubMed

DRA, Complex: DRA:DMA, PubMed

HG2A, Complex: DMA:HG2A, PubMed

Domains

AA: 41-118, PDBID: 1HDM, Subunit A, Seq Identity:100%, Class II histocompatibility antigen, alpha domain

AA: 127-208, PDBID: 1HDM, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 215-259, PDBID: 1HDM, Subunit A, Seq Identity:100%, C1-set C-terminal domain

UniProt annotation for DMA_HUMAN » HLA class II histocompatibility antigen, DM alpha chain
FUNCTION: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.

SUBUNIT: Heterodimer of an alpha chain (DMA) and a beta chain (DMB).

UniProt features for DMA_HUMAN » HLA class II histocompatibility antigen, DM alpha chain
SIGNAL 1 26 Potential.
CHAIN 27 261 HLA class II histocompatibility antigen, DM alpha chain.
DOMAIN 121 215 Ig-like C1-type.
REGION 27 124 Alpha-1.
REGION 125 217 Alpha-2.
REGION 218 233 Connecting peptide (Potential).
DISULFID 50 105
DISULFID 147 202
Amino Acid Sequence for DMA_HUMAN » HLA class II histocompatibility antigen, DM alpha chain
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS NLFPPMLTVN WHDHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL IIYFRKPCSG D