DLL3_HUMAN » Delta-like protein 3

DLL3_HUMAN » Delta-like protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DLL3_HUMAN » Delta-like protein 3 » Drosophila Delta homolog 3;Delta3;
Hydrophobic Thickness 34.8 ± 3.2 Å
Tilt Angle 13 ± 5°
ΔGtransfer -21.4 kcal/mol
ΔGfold -14.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 492-516 (487-518)
Pathways

Notch signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

DLL1, Complex: NOTC2:DLL4:DLL1:DLL3

NOTC1, Complex: DLL3:NOTC1, PubMed

Domains

AA: 278-308, PDBID: 4XBM, Subunit B, Seq Identity:60%, EGF-like domain

AA: 316-349, PDBID: 4XBM, Subunit B, Seq Identity:54%, EGF-like domain

AA: 357-387, PDBID: 4XBM, Subunit B, Seq Identity:60%, EGF-like domain

AA: 395-425, PDBID: 4XBM, Subunit B, Seq Identity:45%, EGF-like domain

AA: 438-459, PDBID: 2YGQ, Subunit A, Seq Identity:43%, Human growth factor-like EGF

UniProt annotation for DLL3_HUMAN » Delta-like protein 3
FUNCTION: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).

SUBUNIT: Can bind and activate Notch-1 or another Notch receptor.

DOMAIN: The DSL domain is required for binding to the Notch receptor.

DISEASE: Spondylocostal dysostosis 1, autosomal recessive (SCDO1) OMIM: A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf- like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life. mutations affecting the gene represented in this entry.

UniProt features for DLL3_HUMAN » Delta-like protein 3
SIGNAL 1 26 Potential.
CHAIN 27 618 Delta-like protein 3.
DOMAIN 176 215 DSL.
DOMAIN 216 249 EGF-like 1.
DOMAIN 274 310 EGF-like 2.
DOMAIN 312 351 EGF-like 3.
DOMAIN 353 389 EGF-like 4.
DOMAIN 391 427 EGF-like 5.
DOMAIN 429 465 EGF-like 6.
DISULFID 220 231 By similarity.
DISULFID 224 237 By similarity.
DISULFID 239 248 By similarity.
DISULFID 278 289 By similarity.
DISULFID 283 298 By similarity.
DISULFID 300 309 By similarity.
DISULFID 316 327 By similarity.
DISULFID 321 339 By similarity.
DISULFID 341 350 By similarity.
DISULFID 357 368 By similarity.
DISULFID 362 377 By similarity.
DISULFID 379 388 By similarity.
DISULFID 395 406 By similarity.
DISULFID 400 415 By similarity.
DISULFID 417 426 By similarity.
DISULFID 433 444 By similarity.
DISULFID 438 453 By similarity.
DISULFID 455 464 By similarity.
Amino Acid Sequence for DLL3_HUMAN » Delta-like protein 3
MVSPRMSGLL SQTVILALIF LPQTRPAGVF ELQIHSFGPG PGPGAPRSPC SARLPCRLFF RVCLKPGLSE EAAESPCALG AALSARGPVY TEQPGAPAPD LPLPDGLLQV PFRDAWPGTF SFIIETWREE LGDQIGGPAW SLLARVAGRR RLAAGGPWAR DIQRAGAWEL RFSYRARCEP PAVGTACTRL CRPRSAPSRC GPGLRPCAPL EDECEAPLVC RAGCSPEHGF CEQPGECRCL EGWTGPLCTV PVSTSSCLSP RGPSSATTGC LVPGPGPCDG NPCANGGSCS ETPRSFECTC PRGFYGLRCE VSGVTCADGP CFNGGLCVGG ADPDSAYICH CPPGFQGSNC EKRVDRCSLQ PCRNGGLCLD LGHALRCRCR AGFAGPRCEH DLDDCAGRAC ANGGTCVEGG GAHRCSCALG FGGRDCRERA DPCAARPCAH GGRCYAHFSG LVCACAPGYM GARCEFPVHP DGASALPAAP PGLRPGDPQR YLLPPALGLL VAAGVAGAAL LLVHVRRRGH SQDAGSRLLA GTPEPSVHAL PDALNNLRTQ EGSGDGPSSS VDWNRPEDVD PQGIYVISAP SIYAREVATP LFPPLHTGRA GQRQHLLFPY PSSILSVK