DLL1_HUMAN » Delta-like protein 1

DLL1_HUMAN » Delta-like protein 1
Magnify DLL1_HUMAN » Delta-like protein 1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DLL1_HUMAN » Delta-like protein 1 » Drosophila Delta homolog 1;Delta1; H-Delta-1;
Hydrophobic Thickness 33.6 ± 5.6 Å
Tilt Angle 46 ± 0°
ΔGtransfer -30.7 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 542-573 (542-576)
Pathways

Notch signaling pathway (KEGG)

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor (Reactome)

Signal Transduction (Reactome)

PDB 4xbm (21-545)
OPM none
Complexes none
Interactions

ADA10, Complex: ADA10:DLL1, PubMed

DLK1, Complex: DLK1:MFNG:DLL1, PubMed

DLL3, Complex: NOTC2:DLL4:DLL1:DLL3

JAG2, Complex: JAG2:DLL1, PubMed

MFNG, Complex: MFNG:DLL1, PubMed

NICA, Complex: NICA:PSN1:APH1A:PEN2:DLL1

NOTC1, Complex: NOTC1:DLL1, PubMed

NOTC2, Complex: NOTC2:DLL1, PubMed

NOTC3, Complex: NOTC3:DLL1, PubMed

Domains

AA: 22-92, PDBID: 4XBM, Subunit B, Seq Identity:100%, N terminus of Notch ligand

AA: 159-221, PDBID: 4XBM, Subunit B, Seq Identity:100%, Delta serrate ligand

AA: 285-324, PDBID: 4XBM, Subunit A, Seq Identity:100%, EGF-like domain

AA: 332-361, PDBID: 4XBM, Subunit B, Seq Identity:100%, EGF-like domain

AA: 370-399, PDBID: 4XBM, Subunit B, Seq Identity:100%, EGF-like domain

AA: 409-439, PDBID: 4XBM, Subunit B, Seq Identity:100%, EGF-like domain

AA: 447-477, PDBID: 4XBM, Subunit B, Seq Identity:60%, EGF-like domain

AA: 490-511, PDBID: 2YGQ, Subunit A, Seq Identity:39%, Human growth factor-like EGF

UniProt annotation for DLL1_HUMAN » Delta-like protein 1
FUNCTION: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

SUBUNIT: Interacts with Notch receptors.

TISSUE SPECIFICITY: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

UniProt features for DLL1_HUMAN » Delta-like protein 1
SIGNAL 1 17 Potential.
CHAIN 18 723 Delta-like protein 1.
DOMAIN 177 221 DSL.
DOMAIN 226 254 EGF-like 1.
DOMAIN 257 285 EGF-like 2.
DOMAIN 292 325 EGF-like 3.
DOMAIN 332 363 EGF-like 4; calcium-binding (Potential).
DOMAIN 370 402 EGF-like 5.
DOMAIN 409 440 EGF-like 6.
DOMAIN 447 478 EGF-like 7; calcium-binding (Potential).
DOMAIN 485 516 EGF-like 8.
DISULFID 179 188 By similarity.
DISULFID 192 204 By similarity.
DISULFID 212 221 By similarity.
DISULFID 226 237 By similarity.
DISULFID 230 243 By similarity.
DISULFID 245 254 By similarity.
DISULFID 257 268 By similarity.
DISULFID 263 274 By similarity.
DISULFID 276 285 By similarity.
DISULFID 292 304 By similarity.
DISULFID 298 314 By similarity.
DISULFID 316 325 By similarity.
DISULFID 332 343 By similarity.
DISULFID 337 352 By similarity.
DISULFID 354 363 By similarity.
DISULFID 370 381 By similarity.
DISULFID 375 391 By similarity.
DISULFID 393 402 By similarity.
DISULFID 409 420 By similarity.
DISULFID 414 429 By similarity.
DISULFID 431 440 By similarity.
DISULFID 447 458 By similarity.
DISULFID 452 467 By similarity.
DISULFID 469 478 By similarity.
DISULFID 485 496 By similarity.
DISULFID 490 505 By similarity.
DISULFID 507 516 By similarity.
Amino Acid Sequence for DLL1_HUMAN » Delta-like protein 1
MGSRCALALA VLSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGAG PPPCACRTFF RVCLKHYQAS VSPEPPCTYG SAVTPVLGVD SFSLPDGGGA DSAFSNPIRF PFGFTWPGTF SLIIEALHTD SPDDLATENP ERLISRLATQ RHLTVGEEWS QDLHSSGRTD LKYSYRFVCD EHYYGEGCSV FCRPRDDAFG HFTCGERGEK VCNPGWKGPY CTEPICLPGC DEQHGFCDKP GECKCRVGWQ GRYCDECIRY PGCLHGTCQQ PWQCNCQEGW GGLFCNQDLN YCTHHKPCKN GATCTNTGQG SYTCSCRPGY TGATCELGID ECDPSPCKNG GSCTDLENSY SCTCPPGFYG KICELSAMTC ADGPCFNGGR CSDSPDGGYS CRCPVGYSGF NCEKKIDYCS SSPCSNGAKC VDLGDAYLCR CQAGFSGRHC DDNVDDCASS PCANGGTCRD GVNDFSCTCP PGYTGRNCSA PVSRCEHAPC HNGATCHERG HRYVCECARG YGGPNCQFLL PELPPGPAVV DLTEKLEGQG GPFPWVAVCA GVILVLMLLL GCAAVVVCVR LRLQKHRPPA DPCRGETETM NNLANCQREK DISVSIIGAT QIKNTNKKAD FHGDHSADKN GFKARYPAVD YNLVQDLKGD DTAVRDAHSK RDTKCQPQGS SGEEKGTPTT LRGGEASERK RPDSGCSTSK DTKYQSVYVI SEEKDECVIA TEV