DLK2_HUMAN » Protein delta homolog 2

DLK2_HUMAN » Protein delta homolog 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DLK2_HUMAN » Protein delta homolog 2 » DLK-2; Epidermal growth factor-like protein 9;EGF-like protein 9;
Hydrophobic Thickness 34.0 ± 1.4 Å
Tilt Angle 3 ± 2°
ΔGtransfer -48.7 kcal/mol
ΔGfold -24.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 304-332 (304-334)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:DLK2, PubMed

PLS1, Complex: PLS1:DLK2, PubMed

Domains

AA: 95-127, PDBID: 1BF9, Subunit A, Seq Identity:54%, EGF-like domain

AA: 142-166, PDBID: 2YGQ, Subunit A, Seq Identity:38%, Human growth factor-like EGF

AA: 178-208, PDBID: 1TOZ, Subunit A, Seq Identity:52%, EGF-like domain

AA: 216-246, PDBID: 1TOZ, Subunit A, Seq Identity:47%, EGF-like domain

UniProt annotation for DLK2_HUMAN » Protein delta homolog 2
FUNCTION: Regulates adipogenesis.
UniProt features for DLK2_HUMAN » Protein delta homolog 2
SIGNAL 1 26 Potential.
CHAIN 27 383 Protein delta homolog 2.
DOMAIN 27 58 EGF-like 1.
DOMAIN 62 89 EGF-like 2.
DOMAIN 91 129 EGF-like 3.
DOMAIN 131 172 EGF-like 4.
DOMAIN 174 210 EGF-like 5; calcium-binding (Potential).
DOMAIN 212 248 EGF-like 6; calcium-binding (Potential).
DISULFID 29 40 By similarity.
DISULFID 33 46 By similarity.
DISULFID 48 57 By similarity.
DISULFID 66 71 By similarity.
DISULFID 79 88 By similarity.
DISULFID 95 107 By similarity.
DISULFID 101 117 By similarity.
DISULFID 119 128 By similarity.
DISULFID 135 148 By similarity.
DISULFID 142 160 By similarity.
DISULFID 162 171 By similarity.
DISULFID 178 189 By similarity.
DISULFID 183 198 By similarity.
DISULFID 200 209 By similarity.
DISULFID 216 227 By similarity.
DISULFID 221 236 By similarity.
DISULFID 238 247 By similarity.
Amino Acid Sequence for DLK2_HUMAN » Protein delta homolog 2
MPSGCRCLHL VCLLCILGAP GQPVRADDCS SHCDLAHGCC APDGSCRCDP GWEGLHCERC VRMPGCQHGT CHQPWQCICH SGWAGKFCDK DEHICTTQSP CQNGGQCMYD GGGEYHCVCL PGFHGRDCER KAGPCEQAGS PCRNGGQCQD DQGFALNFTC RCLVGFVGAR CEVNVDDCLM RPCANGATCL DGINRFSCLC PEGFAGRFCT INLDDCASRP CQRGARCRDR VHDFDCLCPS GYGGKTCELV LPVPDPPTTV DTPLGPTSAV VVPATGPAPH SAGAGLLRIS VKEVVRRQEA GLGEPSLVAL VVFGALTAAL VLATVLLTLR AWRRGVCPPG PCCYPAPHYA PACQDQECQV SMLPAGLPLP RDLPPEPGKT TAL