DLK1_HUMAN » Protein delta homolog 1

DLK1_HUMAN » Protein delta homolog 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DLK1_HUMAN » Protein delta homolog 1 » DLK-1; pG2;
Hydrophobic Thickness 34.8 ± 1.1 Å
Tilt Angle 1 ± 13°
ΔGtransfer -20.6 kcal/mol
ΔGfold -15.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-327 (301-329)
Pathways

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

DLL1, Complex: DLK1:MFNG:DLL1, PubMed

Domains

AA: 92-123, PDBID: 1TOZ, Subunit A, Seq Identity:47%, EGF-like domain

AA: 131-166, PDBID: 4BDW, Subunit A, Seq Identity:44%, EGF-like domain

AA: 174-204, PDBID: 4D90, Subunit A, Seq Identity:54%, EGF-like domain

AA: 212-243, PDBID: 1BF9, Subunit A, Seq Identity:60%, EGF-like domain

UniProt annotation for DLK1_HUMAN » Protein delta homolog 1
FUNCTION: May have a role in neuroendocrine differentiation.

SUBUNIT: Monomer.

TISSUE SPECIFICITY: Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.

UniProt features for DLK1_HUMAN » Protein delta homolog 1
SIGNAL 1 23
CHAIN 24 383 Protein delta homolog 1.
CHAIN 24 303 Fetal antigen 1.
DOMAIN 24 55 EGF-like 1.
DOMAIN 53 86 EGF-like 2.
DOMAIN 88 125 EGF-like 3.
DOMAIN 127 168 EGF-like 4.
DOMAIN 170 206 EGF-like 5.
DOMAIN 208 245 EGF-like 6.
DISULFID 26 37 By similarity.
DISULFID 30 43 By similarity.
DISULFID 45 54 By similarity.
DISULFID 57 68 By similarity.
DISULFID 63 74 By similarity.
DISULFID 76 85 By similarity.
DISULFID 92 103 By similarity.
DISULFID 97 113 By similarity.
DISULFID 115 124 By similarity.
DISULFID 131 144 By similarity.
DISULFID 138 156 By similarity.
DISULFID 158 167 By similarity.
DISULFID 174 185 By similarity.
DISULFID 179 194 By similarity.
DISULFID 196 205 By similarity.
DISULFID 212 223 By similarity.
DISULFID 217 233 By similarity.
DISULFID 235 244 By similarity.
Amino Acid Sequence for DLK1_HUMAN » Protein delta homolog 1
MTATEALLRV LLLLLAFGHS TYGAECFPAC NPQNGFCEDD NVCRCQPGWQ GPLCDQCVTS PGCLHGLCGE PGQCICTDGW DGELCDRDVR ACSSAPCANN GTCVSLDGGL YECSCAPGYS GKDCQKKDGP CVINGSPCQH GGTCVDDEGR ASHASCLCPP GFSGNFCEIV ANSCTPNPCE NDGVCTDIGG DFRCRCPAGF IDKTCSRPVT NCASSPCQNG GTCLQHTQVS YECLCKPEFT GLTCVKKRAL SPQQVTRLPS GYGLAYRLTP GVHELPVQQP EHRILKVSMK ELNKKTPLLT EGQAICFTIL GVLTSLVVLG TVGIVFLNKC ETWVSNLRYN HMLRKKKNLL LQYNSGEDLA VNIIFPEKID MTTFSKEAGD EEI