DJLA_ECOLI » DnaJ-like protein DjlA

DJLA_ECOLI » DnaJ-like protein DjlA
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Topology in Bacterial Gram-negative inner membrane
Topologyextracellular side
cytoplasmic side
DJLA_ECOLI » DnaJ-like protein DjlA »
Hydrophobic Thickness 36.0 ± 2.2 Å
Tilt Angle 1 ± 1°
ΔGtransfer -47.0 kcal/mol
ΔGfold -15.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 3-33 (3-39)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-173, PDBID: 2H5N, Subunit D, Seq Identity:22%, Tellurite resistance protein TerB

AA: 205-269, PDBID: 2LO1, Subunit A, Seq Identity:31%, DnaJ domain

UniProt annotation for DJLA_ECOLI » DnaJ-like protein DjlA
FUNCTION: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.

SUBUNIT: Homodimer.

DOMAIN: The transmembrane domain is a dimerization domain.

UniProt features for DJLA_ECOLI » DnaJ-like protein DjlA
CHAIN 1 271 DnaJ-like protein DjlA.
DOMAIN 205 271 J.
Amino Acid Sequence for DJLA_ECOLI » DnaJ-like protein DjlA
MQYWGKIIGV AVALLMGGGF WGVVLGLLIG HMFDKARSRK MAWFANQRER QALFFATTFE VMGHLTKSKG RVTEADIHIA SQLMDRMNLH GASRTAAQNA FRVGKSDNYP LREKMRQFRS VCFGRFDLIR MFLEIQIQAA FADGSLHPNE RAVLYVIAEE LGISRAQFDQ FLRMMQGGAQ FGGGYQQQTG GGNWQQAQRG PTLEDACNVL GVKPTDDATT IKRAYRKLMS EHHPDKLVAK GLPPEMMEMA KQKAQEIQQA YELIKQQKGF K