DJC30_HUMAN » DnaJ homolog subfamily C member 30

DJC30_HUMAN » DnaJ homolog subfamily C member 30
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
DJC30_HUMAN » DnaJ homolog subfamily C member 30 » Williams-Beuren syndrome chromosomal region 18 protein;
Hydrophobic Thickness 29.8 ± 2.7 Å
Tilt Angle 2 ± 3°
ΔGtransfer -26.4 kcal/mol
ΔGfold -13.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 207-226 (204-226)
Pathways none
PDB 2yua (39-124)
OPM none
Complexes none
Interactions

CREB3, Complex: DJC30:CREB3

Domains

AA: 49-111, PDBID: 2YUA, Subunit A, Seq Identity:100%, DnaJ domain

UniProt annotation for DJC30_HUMAN » DnaJ homolog subfamily C member 30
TISSUE SPECIFICITY: Expressed in brain, heart, kidney, liver, lung, spleen, stomach and testis.

DISEASE: Note=DNAJC30 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

UniProt features for DJC30_HUMAN » DnaJ homolog subfamily C member 30
CHAIN 1 226 DnaJ homolog subfamily C member 30.
DOMAIN 49 114 J.
Amino Acid Sequence for DJC30_HUMAN » DnaJ homolog subfamily C member 30
MAAMRWRWWQ RLLPWRLLQA RGFPQNSAPS LGLGARTYSQ GDCSYSRTAL YDLLGVPSTA TQAQIKAAYY RQCFLYHPDR NSGSAEAAER FTRISQAYVV LGSATLRRKY DRGLLSDEDL RGPGVRPSRT PAPDPGSPRT PPPTSRTHDG SRASPGANRT MFNFDAFYQA HYGEQLERER RLRARREALR KRQEYRSMKG LRWEDTRDTA AIFLIFSIFI IIGFYI