DJC15_HUMAN » DnaJ homolog subfamily C member 15

DJC15_HUMAN » DnaJ homolog subfamily C member 15
Magnify DJC15_HUMAN » DnaJ homolog subfamily C member 15Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
DJC15_HUMAN » DnaJ homolog subfamily C member 15 » Cell growth-inhibiting gene 22 protein;Methylation-controlled J protein;MCJ;
Hydrophobic Thickness 29.2 ± 3.0 Å
Tilt Angle 20 ± 2°
ΔGtransfer -15.3 kcal/mol
ΔGfold -10.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 36-56 (31-56)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 99-150, PDBID: 2guz, Subunit C, Seq Identity:56%, DnaJ domain

UniProt annotation for DJC15_HUMAN » DnaJ homolog subfamily C member 15
FUNCTION: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.

SUBUNIT: Interacts with the TIM23 complex. Directly interacts with PAM16/MAGMAS; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with complex I of the mitochondrial electron transfer chain; this interaction may interfere with the formation of supercomplexes that facilitate the transfer of electrons between complexes (By similarity).

TISSUE SPECIFICITY: Expressed at highest levels in heart, followed by liver and kidney.

DISEASE: Note=Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.

UniProt features for DJC15_HUMAN » DnaJ homolog subfamily C member 15
CHAIN 1 150 DnaJ homolog subfamily C member 15.
DOMAIN 96 150 J.
Amino Acid Sequence for DJC15_HUMAN » DnaJ homolog subfamily C member 15
MAARGVIAPV GESLRYAEYL QPSAKRPDAD VDQQRLVRSL IAVGLGVAAL AFAGRYAFRI WKPLEQVITE TAKKISTPSF SSYYKGGFEQ KMSRREAGLI LGVSPSAGKA KIRTAHRRVM ILNHPDKGGS PYVAAKINEA KDLLETTTKH