DJB14_HUMAN » DnaJ homolog subfamily B member 14

DJB14_HUMAN » DnaJ homolog subfamily B member 14
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
DJB14_HUMAN » DnaJ homolog subfamily B member 14 »
Hydrophobic Thickness 32.0 ± 2.7 Å
Tilt Angle 16 ± 2°
ΔGtransfer -21.8 kcal/mol
ΔGfold -14.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 247-269 (247-271)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:DJB14, PubMed

Domains

AA: 108-169, PDBID: 2CTP, Subunit A, Seq Identity:84%, DnaJ domain

AA: 265-371, Domain of unknown function (DUF1977)

UniProt annotation for DJB14_HUMAN » DnaJ homolog subfamily B member 14
FUNCTION: Acts as a co-chaperone with HSPA8 and promotes the degradation of misfolded transmembrane proteins in the ER- associated degradation (ERAD) pathway.

SUBUNIT: Interacts (via J domain) with HSPA8/Hsc70.

UniProt features for DJB14_HUMAN » DnaJ homolog subfamily B member 14
CHAIN 1 379 DnaJ homolog subfamily B member 14.
DOMAIN 108 172 J.
Amino Acid Sequence for DJB14_HUMAN » DnaJ homolog subfamily B member 14
MEGNRDEAEK CVEIAREALN AGNREKAQRF LQKAEKLYPL PSARALLEII MKNGSTAGNS PHCRKPSGSG DQSKPNCTKD STSGSGEGGK GYTKDQVDGV LSINKCKNYY EVLGVTKDAG DEDLKKAYRK LALKFHPDKN HAPGATDAFK KIGNAYAVLS NPEKRKQYDL TGNEEQACNH QNNGRFNFHR GCEADITPED LFNIFFGGGF PSGSVHSFSN GRAGYSQQHQ HRHSGHEREE ERGDGGFSVF IQLMPIIVLI LVSLLSQLMV SNPPYSLYPR SGTGQTIKMQ TENLGVVYYV NKDFKNEYKG MLLQKVEKSV EEDYVTNIRN NCWKERQQKT DMQYAAKVYR DDRLRRKADA LSMDNCKELE RLTSLYKGG