DCC_HUMAN » Netrin receptor DCC

DCC_HUMAN » Netrin receptor DCC
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DCC_HUMAN » Netrin receptor DCC » Colorectal cancer suppressor;Immunoglobulin superfamily DCC subclass member 1;Tumor suppressor protein DCC;
Hydrophobic Thickness 38.4 ± 4.4 Å
Tilt Angle 1 ± 4°
ΔGtransfer -31.4 kcal/mol
ΔGfold -24.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1097-1122 (1096-1127)
Pathways

Apoptosis (Reactome)

Axon guidance (KEGG)

Cell-Cell communication (Reactome)

Colorectal cancer (KEGG)

Developmental Biology (Reactome)

Pathways in cancer (KEGG)

PDB 2ed7 (419-524), 2ed8 (528-620), 2ed9 (602-718), 2edb (716-818), 2edd (833-942), 2ede (944-1044), 3au4 (B=1390-1447), 4urt (B=844-1043)
OPM none
Complexes none
Interactions

ITB5, Complex: DCC:ITB5, PubMed

ROBO2, Complex: ROBO2:DCC, PubMed

Domains

AA: 140-230, PDBID: 3LAF, Subunit A, Seq Identity:94%, Immunoglobulin I-set domain

AA: 240-327, PDBID: 3LAF, Subunit A, Seq Identity:97%, Immunoglobulin I-set domain

AA: 331-417, PDBID: 3LAF, Subunit A, Seq Identity:97%, Immunoglobulin I-set domain

AA: 430-514, PDBID: 2ED7, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 529-610, PDBID: 2ED8, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 624-708, PDBID: 2ED9, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 727-807, PDBID: 2EDB, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 845-932, PDBID: 2EDD, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 946-1034, PDBID: 2EDE, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 1148-1445, PDBID: 3AU4, Subunit B, Seq Identity:100%, Neogenin C-terminus

UniProt annotation for DCC_HUMAN » Netrin receptor DCC
FUNCTION: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

SUBUNIT: Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with DSCAM. Interacts with PTK2/FAK1 and MAPK1. Interacts with NTN1 (By similarity). Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1 (By similarity).

TISSUE SPECIFICITY: Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.

DISEASE: Mirror movements 1 (MRMV1) OMIM: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. mutations affecting the gene represented in this entry.

MISCELLANEOUS: Inactivation of DCC due to allelic deletion and/or point mutations is related to lymphatic and hematogenous metastatic tumor dissemination.

UniProt features for DCC_HUMAN » Netrin receptor DCC
SIGNAL 1 25 Potential.
CHAIN 26 1447 Netrin receptor DCC.
DOMAIN 26 135 Ig-like C2-type 1.
DOMAIN 139 229 Ig-like C2-type 2.
DOMAIN 234 326 Ig-like C2-type 3.
DOMAIN 331 416 Ig-like C2-type 4.
DOMAIN 429 520 Fibronectin type-III 1.
DOMAIN 528 616 Fibronectin type-III 2.
DOMAIN 622 714 Fibronectin type-III 3.
DOMAIN 726 814 Fibronectin type-III 4.
DOMAIN 843 939 Fibronectin type-III 5.
DOMAIN 944 1041 Fibronectin type-III 6.
REGION 1432 1439 Interaction with MYO10.
DISULFID 61 117 By similarity.
DISULFID 161 212 By similarity.
DISULFID 261 310 By similarity.
DISULFID 352 400 By similarity.
Amino Acid Sequence for DCC_HUMAN » Netrin receptor DCC
MENSLRCVWV PKLAFVLFGA SLLSAHLQVT GFQIKAFTAL RFLSEPSDAV TMRGGNVLLD CSAESDRGVP VIKWKKDGIH LALGMDERKQ QLSNGSLLIQ NILHSRHHKP DEGLYQCEAS LGDSGSIISR TAKVAVAGPL RFLSQTESVT AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL TPIPGDSRVV VLPSGALQIS RLQPGDIGIY RCSARNPASS RTGNEAEVRI LSDPGLHRQL YFLQRPSNVV AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV TDDDSGMYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF ECTVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC VAENEAGNAQ TSAQLIVPKP AIPSSSVLPS APRDVVPVLV SSRFVRLSWR PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLQAVSTS PTSILITWEP PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYSLRFLA YNRYGPGVST DDITVVTLSD VPSAPPQNVS LEVVNSRSIK VSWLPPPSGT QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSVPDL STPMLPPVGV QAVALTHDAV RVSWADNSVP KNQKTSEVRL YTVRWRTSFS ASAKYKSEDT TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD FTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI SGDRLTHQIM DLNLDTMYYF RIQARNSKGV GPLSDPILFR TLKVEHPDKM ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV IIVVTVGVIT VLVVVIVAVI CTRRSSAQQR KKRATHSAGK RKGSQKDLRP PDLWIHHEEM EMKNIEKPSG TDPAGRDSPI QSCQDLTPVS HSQSETQLGS KSTSHSGQDT EEAGSSMSTL ERSLAARRAP RAKLMIPMDA QSNNPAVVSA IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRSQS VSEGPTTQQP PMLPPSQPEH SSSEEAPSRT IPTACVRPTH PLRSFANPLL PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK TASLGLAGKA RSPLLPVSVP TAPEVSEESH KPTEDSANVY EQDDLSEQMA SLEGLMKQLN AITGSAF