DCBD2_HUMAN » Discoidin, CUB and LCCL domain-containing protein 2

DCBD2_HUMAN » Discoidin, CUB and LCCL domain-containing protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
DCBD2_HUMAN » Discoidin, CUB and LCCL domain-containing protein 2 » CUB, LCCL and coagulation factor V/VIII-homology domains protein 1;Endothelial and smooth muscle cell-derived neuropilin-like protein;
Hydrophobic Thickness 42.8 ± 4.2 Å
Tilt Angle 9 ± 8°
ΔGtransfer -33.9 kcal/mol
ΔGfold -26.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 525-553 (525-558)
Pathways none
PDB none
OPM none
Complexes none
Interactions

EGFR, Complex: EGFR:DCBD2

SEM4B, Complex: SEM4B:DCBD2, PubMed

Domains

AA: 72-184, PDBID: 3POB, Subunit A, Seq Identity:33%, CUB domain

AA: 187-285, PDBID: 1JBI, Subunit A, Seq Identity:22%, LCCL domain

AA: 307-446, PDBID: 1SDD, Subunit B, Seq Identity:47%, F5/8 type C domain

UniProt annotation for DCBD2_HUMAN » Discoidin, CUB and LCCL domain-containing protein 2
TISSUE SPECIFICITY: Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells.

INDUCTION: Increased in lung cancers during the process of tumor progression.

UniProt features for DCBD2_HUMAN » Discoidin, CUB and LCCL domain-containing protein 2
SIGNAL 1 66 Potential.
CHAIN 67 775 Discoidin, CUB and LCCL domain-containing protein 2.
DOMAIN 72 186 CUB.
DOMAIN 187 285 LCCL.
DOMAIN 292 449 F5/8 type C.
DISULFID 72 99 By similarity.
DISULFID 126 148 By similarity.
DISULFID 215 237 By similarity.
DISULFID 292 449 By similarity.
Amino Acid Sequence for DCBD2_HUMAN » Discoidin, CUB and LCCL domain-containing protein 2
MASRAVVRAR RCPQCPQVRA AAAAPAWAAL PLSRSLPPCS NSSSFSMPLF LLLLLVLLLL LEDAGAQQGD GCGHTVLGPE SGTLTSINYP QTYPNSTVCE WEIRVKMGER VRIKFGDFDI EDSDSCHFNY LRIYNGIGVS RTEIGKYCGL GLQMNHSIES KGNEITLLFM SGIHVSGRGF LASYSVIDKQ DLITCLDTAS NFLEPEFSKY CPAGCLLPFA EISGTIPHGY RDSSPLCMAG VHAGVVSNTL GGQISVVISK GIPYYESSLA NNVTSVVGHL STSLFTFKTS GCYGTLGMES GVIADPQITA SSVLEWTDHT GQENSWKPKK ARLKKPGPPW AAFATDEYQW LQIDLNKEKK ITGIITTGST MVEHNYYVSA YRILYSDDGQ KWTVYREPGV EQDKIFQGNK DYHQDVRNNF LPPIIARFIR VNPTQWQQKI AMKMELLGCQ FIPKGRPPKL TQPPPPRNSN DLKNTTAPPK IAKGRAPKFT QPLQPRSSNE FPAQTEQTTA SPDIRNTTVT PNVTKDVALA AVLVPVLVMV LTTLILILVC AWHWRNRKKK TEGTYDLPYW DRAGWWKGMK QFLPAKAVDH EETPVRYSSS EVNHLSPREV TTVLQADSAE YAQPLVGGIV GTLHQRSTFK PEEGKEAGYA DLDPYNSPGQ EVYHAYAEPL PITGPEYATP IIMDMSGHPT TSVGQPSTST FKATGNQPPP LVGTYNTLLS RTDSCSSAQA QYDTPKAGKP GLPAPDELVY QVPQSTQEVS GAGRDGECDV FKEIL