CYAG_DICDI » Adenylate cyclase, germination specific

CYAG_DICDI » Adenylate cyclase, germination specific
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CYAG_DICDI » Adenylate cyclase, germination specific » ATP pyrophosphate-lyase;Adenylyl cyclase;
Hydrophobic Thickness 34.4 ± 0.8 Å
Tilt Angle 3 ± 0°
ΔGtransfer -42.8 kcal/mol
ΔGfold -17.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 17-42 (17-47)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 88-275, PDBID: 3T4J, Subunit B, Seq Identity:13%, CHASE domain

AA: 387-572, PDBID: 1YK9, Subunit A, Seq Identity:29%, Adenylate and Guanylate cyclase catalytic domain

UniProt annotation for CYAG_DICDI » Adenylate cyclase, germination specific
FUNCTION: Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain.

CATALYTIC ACTIVITY: ATP = 3",5"-cyclic AMP + diphosphate.

ENZYME REGULATION: Insensitive to guanine nucleotides.

DEVELOPMENTAL STAGE: After fruiting bodies have been formed and during germination.

UniProt features for CYAG_DICDI » Adenylate cyclase, germination specific
CHAIN 1 858 Adenylate cyclase, germination specific.
DOMAIN 86 317 CHASE.
DOMAIN 396 526 Guanylate cyclase.
Amino Acid Sequence for CYAG_DICDI » Adenylate cyclase, germination specific
MKKTFVKILS KSYVEGYPVG FFIGLIILAI FGSMVCIFSF MHYSEEENSN IQMDLERSSK QIIHNIQMNA MYLLSSIDTL KALYYVNPNF DRNDFNVFLN TTLKNSEFQY LFWIKKINNN DRNCFEEKFS KEIKDTFQIY SFDENTNSIH VAKNKSSYFP ILHAFPDINK DIIGLDINST DYMNETIKKS IFNKKPTVHL NKKVLLSKRN IDILIVSPII VTKTLESTNE TMEDMSHISS GLFLMEKNVQ ASRIEVENGN DFTIFLSTTN GEIVYQENYL NFKTLYQVHE SGLFEDRLKY ESSLKIADCV LKLWIFTTEE YENNSKTYLP LLVSIISAVI LVLLITYSVD QRKQKSLIAK IMREKNNLIN KILPLEVSVK LENGEDVVAE RSNNACVFFL DIAGFTRFSS IHSPEQVIQV LIKIFNSMDL LCAKHGIEKI KTIGDAYMAT CGIFPKCDDI RHNTYKMLGF AMDVLEFIPK EMSFHLGLQV RVGIHCGPVI SGVISGYAKP HFDVWGDTVN VASRMESTGI AGQIHVSDRV YQLGKEDFNF SERCDIIHVK GKGRMKTWYL MGKKSSDFSL KKDFSRSRVQ PSLFNRKQSH VHCIYPEFPS GLQALNIENN LNNTDAGCEN CSKILKKTYA YSPDHSTSNY YYHGDDNSPP PPSLNSNDLI DGSEYHDDPF PSDSNVGYHD TSKDIKEDEN EQNETLLFNQ EQLKKKQIEN IQRDLSLNDS IEAIKILNNN NNNNINDNNI NNTNLNNNNN DININNSDNV NNYENNNNFS DKIENNDGDN NNINDNNYKS TNENNIKSKT LFKDSKSLIN DIKMAKENCD NNDDNNNNNN NNNNNNNNDE NVESKKNK