CY1_YEAST » Cytochrome c1, heme protein, mitochondrial

CY1_YEAST » Cytochrome c1, heme protein, mitochondrial
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
CY1_YEAST » Cytochrome c1, heme protein, mitochondrial » Complex III subunit 4;Complex III subunit IV;Cytochrome b-c1 complex subunit 4;Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit;Cytochrome c-1;
Hydrophobic Thickness 30.6 ± 2.2 Å
Tilt Angle 26 ± 0°
ΔGtransfer -15.9 kcal/mol
ΔGfold -8.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, Reactome
Topology Out
TM Segments 267-290 (263-290)
Pathways

Amino sugar and nucleotide sugar metabolism (KEGG)

Biosynthesis of secondary metabolites (KEGG)

Fructose and mannose metabolism (KEGG)

Mitochondrial Protein Import (yeast) (Reactome)

Nitrogen metabolism (KEGG)

Oxidative phosphorylation (KEGG)

PDB 1kyo (D/O=62-309), 3cx5 (D/O=62-309), 3cxh (D/O=62-309), 1ezv (D=62-306), 1kb9 (D=62-307), 1p84 (D=62-307), 2ibz (D=62-309), 4pd4 (D=62-309)
OPM 1l0l (BOVIN), 1pp9 (BOVIN), 1zrt (RHOCA), 2a06 (BOVIN), 2fyu (BOVIN), 2qjy (RHOSH), 2ybb (BOVIN), 2yiu (PARDE), 3cx5
Complexes

CY1:CYB:UCRI_RHOSH

UCRI:CYB:CY1_PARDE

CYB:UCRI:CY1_RHOCA

HVM60:QCR6:QCR7:CYB:KV5AE:CY1:QCR1:QCR2:UCRI:QCR8:QCR9_YEAST

CY1:QCR6:QCR7:QCR9:CYB:QCR8:UCRI:QCR2:QCR1_BOVIN

QCR10:CY1:QCR6:QCR7:QCR9:CYB:QCR8:UCRI:QCR2:QCR1_BOVIN

CYC1:QCR6:QCR7:CYB:CY1:QCR1:QCR2:UCRI:QCR8:QCR9_YEAST

QCR10:CYC:COX1:COX3:COX41:COX5A:COX5B:CX6B1:COX7C:COX6C:CX7A1:CX6A2:COX8B:COX7B:COX2:CY1:QCR6:QCR7:QCR9:CYB:QCR8:UCRI:QCR2:QCR1:NQO6:NQO5:NQO4:NQO2:NQO1:NQO3:NQO9:NQO15_BOVIN

Interactions

ALG1, Complex: ALG1:CY1

COA1, Complex: ADT1:COX5A:COA1:COX14:CY1:COX1:COX15:COX4:MSS51:QCR1:SHY1:QCR2:COX6, PubMed

COX13, Complex: QCR2:COX9:QCR1:MSS51:COX13:ADT2:COX4:QCR7:ADH3:MPCP:QCR10:CY1:COX12:GGC1:COX5A:COX6:CYB:DHSB:PIC2:COX2:UCRI, PubMed

COX14, Complex: QCR6:CY1:COX2:COX3:COX1:COX4:NUP42:COX14:SHY1, PubMed

COX5A, Complex: ADT1:COX5A:COA1:COX14:CY1:COX1:COX15:COX4:MSS51:QCR1:SHY1:QCR2:COX6, PubMed

COX5B, Complex: CY1:COX5B

COX7, Complex: ATPA:ATPB:QCR2:CY1:COX7:TIM44:TIM23:PAM17:TIM16, PubMed

COX9, Complex: QCR2:COX9:QCR1:MSS51:COX13:ADT2:COX4:QCR7:ADH3:MPCP:QCR10:CY1:COX12:GGC1:COX5A:COX6:CYB:DHSB:PIC2:COX2:UCRI, PubMed

FAR10, Complex: CY1:FAR10

FCJ1, Complex: CY1:FCJ1, PubMed

GPI8, Complex: CY1:GPI8

MIA40, Complex: CY1:MIA40

NVJ1, Complex: CY1:NVJ1, PubMed

QCR8, Complex: QCR7:QCR2:QCR8:QCR1:UCRI:CYB:QCR9:QCR6:CY1:QCR10, PubMed

QCR9, Complex: CY1:CYB:QCR10:QCR1:QCR2:QCR6:QCR7:QCR8:QCR9:UCRI, PDBID: 1be3

SC6B1, Complex: SC6B1:CY1

SKN1, Complex: SKN1:CY1

TGL3, Complex: TGL3:CY1

UBC6, Complex: CY1:UBC6

UCRI, Complex: CYB:UCRI:CY1:QCR6:QCR7:QCR9:QCR8:UCRI:QCR2:QCR1, PDBID: 1BCC

YN8B, Complex: CY1:YN8B

Domains

AA: 76-295, PDBID: 1EZV, Subunit D, Seq Identity:100%, Cytochrome C1 family

UniProt annotation for CY1_YEAST » Cytochrome c1, heme protein, mitochondrial
FUNCTION: Heme-containing component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c.

SUBUNIT: Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

MISCELLANEOUS: Present with 39900 molecules/cell in log phase SD medium.

UniProt features for CY1_YEAST » Cytochrome c1, heme protein, mitochondrial
TRANSIT 1 61 Mitochondrion.
CHAIN 62 309 Cytochrome c1, heme protein, mitochondrial.
DOMAIN 88 241 Cytochrome c.
Amino Acid Sequence for CY1_YEAST » Cytochrome c1, heme protein, mitochondrial
MFSNLSKRWA QRTLSKSFYS TATGAASKSG KLTQKLVTAG VAAAGITAST LLYADSLTAE AMTAAEHGLH APAYAWSHNG PFETFDHASI RRGYQVYREV CAACHSLDRV AWRTLVGVSH TNEEVRNMAE EFEYDDEPDE QGNPKKRPGK LSDYIPGPYP NEQAARAANQ GALPPDLSLI VKARHGGCDY IFSLLTGYPD EPPAGVALPP GSNYNPYFPG GSIAMARVLF DDMVEYEDGT PATTSQMAKD VTTFLNWCAE PEHDERKRLG LKTVIILSSL YLLSIWVKKF KWAGIKTRKF VFNPPKPRK