CXL16_HUMAN » C-X-C motif chemokine 16

CXL16_HUMAN » C-X-C motif chemokine 16
Magnify CXL16_HUMAN » C-X-C motif chemokine 16Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CXL16_HUMAN » C-X-C motif chemokine 16 » Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein;SR-PSOX; Small-inducible cytokine B16;Transmembrane chemokine CXCL16;
Hydrophobic Thickness 32.4 ± 2.2 Å
Tilt Angle 7 ± 4°
ΔGtransfer -45.7 kcal/mol
ΔGfold -20.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 202-226 (198-231)
Pathways

Chemokine signaling pathway (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:CXL16, PubMed

KASH5, Complex: CXL16:KASH5

Domains none
UniProt annotation for CXL16_HUMAN » C-X-C motif chemokine 16
FUNCTION: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

TISSUE SPECIFICITY: Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

UniProt features for CXL16_HUMAN » C-X-C motif chemokine 16
SIGNAL 1 29 Potential.
CHAIN 30 254 C-X-C motif chemokine 16.
REGION 32 107 Chemokine.
DISULFID 38 68 By similarity.
DISULFID 40 82 By similarity.
Amino Acid Sequence for CXL16_HUMAN » C-X-C motif chemokine 16
MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP SVQFMNRLRK HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK ECGHAYSGIV AHQKHLLPTS PPISQASEGA SSDIHTPAQM LLSTLQSTQR PTLPVGSLSS DKELTRPNET TIHTAGHSLA AGPEAGENQK QPEKNAGPTA RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD LPVHYIPVAP DSNT