CXAR_HUMAN » Coxsackievirus and adenovirus receptor

CXAR_HUMAN » Coxsackievirus and adenovirus receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CXAR_HUMAN » Coxsackievirus and adenovirus receptor » CAR; hCAR; CVB3-binding protein;Coxsackievirus B-adenovirus receptor;HCVADR;
Hydrophobic Thickness 34.4 ± 0.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -49.7 kcal/mol
ΔGfold -22.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 236-260 (232-267)
Pathways

Hemostasis (Reactome)

Immune System (Reactome)

Viral myocarditis (KEGG)

PDB 2npl (142-235), 1jew (21-140), 1rsf (21-144), 2j1k (A/B...=15-140), 2w9l (A/B...=16-139), 1eaj (A/B=15-140), 1f5w (A/B=15-140), 2wbw (B=15-138), 2j12 (B=15-140), 3j6l (B=15-140), 1kac (B=22-144), 1p69 (B=22-144), 1p6a (B=22-144), 3j6m (B=22-144), 3j6n (K=20-233), 3j6o (S=20-236)
OPM none
Complexes

CXAR:JAML1_MOUSE

CXAR:CXAR_HUMAN

Interactions

CXAR, Complex: Homodimer of coxsackie virus and adenovirus receptor, PDBID: 1EAJ

JAML1, Complex: CXAR:JAML1, PDBID: 3MJ7

Domains

AA: 23-138, PDBID: 1EAJ, Subunit B, Seq Identity:100%, Immunoglobulin V-set domain

AA: 149-225, PDBID: 2NPL, Subunit X, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for CXAR_HUMAN » Coxsackievirus and adenovirus receptor
FUNCTION: Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair.

SUBUNIT: Monomer. May form homodimer. Interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with AMICA1 (homodimeric form). Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor. Interacts with adenovirus subgroups A, C, D, E and F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 and B6 capsid proteins and acts as a receptor for these viruses.

TISSUE SPECIFICITY: Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.

DOMAIN: The Ig-like C2-type 1 domain mediates homodimerization and interaction with AMICA1.

DOMAIN: The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.

UniProt features for CXAR_HUMAN » Coxsackievirus and adenovirus receptor
SIGNAL 1 19 Potential.
CHAIN 20 365 Coxsackievirus and adenovirus receptor.
DOMAIN 20 134 Ig-like C2-type 1.
DOMAIN 141 228 Ig-like C2-type 2.
MOTIF 360 365 PDZ-binding.
DISULFID 41 120
DISULFID 162 212 By similarity.
Amino Acid Sequence for CXAR_HUMAN » Coxsackievirus and adenovirus receptor
MALLLCFVLL CGVVDFARSL SITTPEEMIE KAKGETAYLP CKFTLSPEDQ GPLDIEWLIS PADNQKVDQV IILYSGDKIY DDYYPDLKGR VHFTSNDLKS GDASINVTNL QLSDIGTYQC KVKKAPGVAN KKIHLVVLVK PSGARCYVDG SEEIGSDFKI KCEPKEGSLP LQYEWQKLSD SQKMPTSWLA EMTSSVISVK NASSEYSGTY SCTVRNRVGS DQCLLRLNVV PPSNKAGLIA GAIIGTLLAL ALIGLIIFCC RKKRREEKYE KEVHHDIRED VPPPKSRTST ARSYIGSNHS SLGSMSPSNM EGYSKTQYNQ VPSEDFERTP QSPTLPPAKV AAPNLSRMGA IPVMIPAQSK DGSIV