CUZD1_HUMAN » CUB and zona pellucida-like domain-containing protein 1

CUZD1_HUMAN » CUB and zona pellucida-like domain-containing protein 1
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
CUZD1_HUMAN » CUB and zona pellucida-like domain-containing protein 1 » CUB and ZP domain-containing protein 1; Transmembrane protein UO-44;
Hydrophobic Thickness 30.4 ± 4.0 Å
Tilt Angle 29 ± 0°
ΔGtransfer -21.8 kcal/mol
ΔGfold -12.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 568-590 (568-597)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 50-143, PDBID: 1SPP, Subunit B, Seq Identity:27%, CUB domain

AA: 154-262, PDBID: 3KQ4, Subunit B, Seq Identity:44%, CUB domain

AA: 277-517, PDBID: 3NK3, Subunit B, Seq Identity:25%, Zona pellucida-like domain

UniProt annotation for CUZD1_HUMAN » CUB and zona pellucida-like domain-containing protein 1
FUNCTION: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.

TISSUE SPECIFICITY: Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue.

UniProt features for CUZD1_HUMAN » CUB and zona pellucida-like domain-containing protein 1
SIGNAL 1 24 Potential.
CHAIN 25 607 CUB and zona pellucida-like domain- containing protein 1.
DOMAIN 25 146 CUB 1.
DOMAIN 154 265 CUB 2.
DOMAIN 276 519 ZP.
DISULFID 17 58 By similarity.
DISULFID 85 107 By similarity.
DISULFID 154 180 By similarity.
DISULFID 207 229 By similarity.
DISULFID 442 498 By similarity.
Amino Acid Sequence for CUZD1_HUMAN » CUB and zona pellucida-like domain-containing protein 1
MELVRRLMPL TLLILSCLAE LTMAEAEGNA SCTVSLGGAN MAETHKAMIL QLNPSENCTW TIERPENKSI RIIFSYVQLD PDGSCESENI KVFDGTSSNG PLLGQVCSKN DYVPVFESSS STLTFQIVTD SARIQRTVFV FYYFFSPNIS IPNCGGYLDT LEGSFTSPNY PKPHPELAYC VWHIQVEKDY KIKLNFKEIF LEIDKQCKFD FLAIYDGPST NSGLIGQVCG RVTPTFESSS NSLTVVLSTD YANSYRGFSA SYTSIYAENI NTTSLTCSSD RMRVIISKSY LEAFNSNGNN LQLKDPTCRP KLSNVVEFSV PLNGCGTIRK VEDQSITYTN IITFSASSTS EVITRQKQLQ IIVKCEMGHN STVEIIYITE DDVIQSQNAL GKYNTSMALF ESNSFEKTIL ESPYYVDLNQ TLFVQVSLHT SDPNLVVFLD TCRASPTSDF ASPTYDLIKS GCSRDETCKV YPLFGHYGRF QFNAFKFLRS MSSVYLQCKV LICDSSDHQS RCNQGCVSRS KRDISSYKWK TDSIIGPIRL KRDRSASGNS GFQHETHAEE TPNQPFNSVH LFSFMVLALN VVTVATITVR HFVNQRADYK YQKLQNY