CSTN3_HUMAN » Calsyntenin-3

CSTN3_HUMAN » Calsyntenin-3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CSTN3_HUMAN » Calsyntenin-3 » Alcadein-beta;Alc-beta;
Hydrophobic Thickness 34.0 ± 3.6 Å
Tilt Angle 42 ± 0°
ΔGtransfer -32.2 kcal/mol
ΔGfold -21.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 843-871 (843-875)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 150-239, PDBID: 3UBH, Subunit A, Seq Identity:31%, Cadherin domain

UniProt annotation for CSTN3_HUMAN » Calsyntenin-3
FUNCTION: May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.

SUBUNIT: Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. Interacts with low affinity with KLC1 (By similarity).

TISSUE SPECIFICITY: According to PubMed, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern).

DOMAIN: Binds synaptic Ca(2+) with its cytoplasmic domain.

UniProt features for CSTN3_HUMAN » Calsyntenin-3
SIGNAL 1 19 Potential.
CHAIN 20 956 Calsyntenin-3.
DOMAIN 29 145 Cadherin 1.
DOMAIN 146 246 Cadherin 2.
Amino Acid Sequence for CSTN3_HUMAN » Calsyntenin-3
MTLLLLPLLL ASLLASCSCN KANKHKPWIE AEYQGIVMEN DNTVLLNPPL FALDKDAPLR YAGEICGFRL HGSGVPFEAV ILDKATGEGL IRAKEPVDCE AQKEHTFTIQ AYDCGEGPDG ANTKKSHKAT VHVRVNDVNE FAPVFVERLY RAAVTEGKLY DRILRVEAID GDCSPQYSQI CYYEILTPNT PFLIDNDGNI ENTEKLQYSG ERLYKFTVTA YDCGKKRAAD DAEVEIQVKP TCKPSWQGWN KRIEYAPGAG SLALFPGIRL ETCDEPLWNI QATIELQTSH VAKGCDRDNY SERALRKLCG AATGEVDLLP MPGPNANWTA GLSVHYSQDS SLIYWFNGTQ AVQVPLGGPS GLGSGPQDSL SDHFTLSFWM KHGVTPNKGK KEEETIVCNT VQNEDGFSHY SLTVHGCRIA FLYWPLLESA RPVKFLWKLE QVCDDEWHHY ALNLEFPTVT LYTDGISFDP ALIHDNGLIH PPRREPALMI GACWTEEKNK EKEKGDNSTD TTQGDPLSIH HYFHGYLAGF SVRSGRLESR EVIECLYACR EGLDYRDFES LGKGMKVHVN PSQSLLTLEG DDVETFNHAL QHVAYMNTLR FATPGVRPLR LTTAVKCFSE ESCVSIPEVE GYVVVLQPDA PQILLSGTAH FARPAVDFEG TNGVPLFPDL QITCSISHQV EAKKDESWQG TVTDTRMSDE IVHNLDGCEI SLVGDDLDPE RESLLLDTTS LQQRGLELTN TSAYLTIAGV ESITVYEEIL RQARYRLRHG AALYTRKFRL SCSEMNGRYS SNEFIVEVNV LHSMNRVAHP SHVLSSQQFL HRGHQPPPEM AGHSLASSHR NSMIPSAATL IIVVCVGFLV LMVVLGLVRI HSLHRRVSGA GGPPGASSDP KDPDLFWDDS ALTIIVNPME SYQNRQSCVT GAVGGQQEDE DSSDSEVADS PSSDERRIIE TPPHRY