CSTN2_HUMAN » Calsyntenin-2

CSTN2_HUMAN » Calsyntenin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CSTN2_HUMAN » Calsyntenin-2 » Alcadein-gamma;Alc-gamma;
Hydrophobic Thickness 34.0 ± 3.4 Å
Tilt Angle 45 ± 5°
ΔGtransfer -29.6 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 828-856 (828-858)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 165-254, PDBID: 3UBH, Subunit A, Seq Identity:36%, Cadherin domain
UniProt annotation for CSTN2_HUMAN » Calsyntenin-2
FUNCTION: May modulate calcium-mediated postsynaptic signals.

TISSUE SPECIFICITY: Restricted to the brain.

DOMAIN: Binds synaptic Ca(2+) with its cytoplasmic domain.

UniProt features for CSTN2_HUMAN » Calsyntenin-2
SIGNAL 1 20 Potential.
CHAIN 21 955 Calsyntenin-2.
DOMAIN 44 160 Cadherin 1.
DOMAIN 161 280 Cadherin 2.
Amino Acid Sequence for CSTN2_HUMAN » Calsyntenin-2
MLPGRLCWVP LLLALGVGSG SGGGGDSRQR RLLAAKVNKH KPWIETSYHG VITENNDTVI LDPPLVALDK DAPVPFAGEI CAFKIHGQEL PFEAVVLNKT SGEGRLRAKS PIDCELQKEY TFIIQAYDCG AGPHETAWKK SHKAVVHIQV KDVNEFAPTF KEPAYKAVVT EGKIYDSILQ VEAIDEDCSP QYSQICNYEI VTTDVPFAID RNGNIRNTEK LSYDKQHQYE ILVTAYDCGQ KPAAQDTLVQ VDVKPVCKPG WQDWTKRIEY QPGSGSMPLF PSIHLETCDG AVSSLQIVTE LQTNYIGKGC DRETYSEKSL QKLCGASSGI IDLLPSPSAA TNWTAGLLVD SSEMIFKFDG RQGAKIPDGI VPKNLTDQFT ITMWMKHGPS PGVRAEKETI LCNSDKTEMN RHHYALYVHN CRLVFLLRKD FDQADTFRPA EFHWKLDQIC DKEWHYYVIN VEFPVVTLYM DGATYEPYLV TNDWPIHPSH IAMQLTVGAC WQGGEVTKPQ FAQFFHGSLA SLTIRPGKME SQKVISCLQA CKEGLDINSL ESLGQGIKYH FNPSQSILVM EGDDIGNINR ALQKVSYINS RQFPTAGVRR LKVSSKVQCF GEDVCISIPE VDAYVMVLQA IEPRITLRGT DHFWRPAAQF ESARGVTLFP DIKIVSTFAK TEAPGDVKTT DPKSEVLEEM LHNLDFCDIL VIGGDLDPRQ ECLELNHSEL HQRHLDATNS TAGYSIYGVG SMSRYEQVLH HIRYRNWRPA SLEARRFRIK CSELNGRYTS NEFNLEVSIL HEDQVSDKEH VNHLIVQPPF LQSVHHPESR SSIQHSSVVP SIATVVIIIS VCMLVFVVAM GVYRVRIAHQ HFIQETEAAK ESEMDWDDSA LTITVNPMEK HEGPGHGEDE TEGEEEEEAE EEMSSSSGSD DSEEEEEEEG MGRGRHGQNG ARQAQLEWDD STLPY