CSTN1_HUMAN » Calsyntenin-1

CSTN1_HUMAN » Calsyntenin-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CSTN1_HUMAN » Calsyntenin-1 » Alcadein-alpha;Alc-alpha; Alzheimer-related cadherin-like protein;Non-classical cadherin XB31alpha;
Hydrophobic Thickness 32.8 ± 2.0 Å
Tilt Angle 4 ± 2°
ΔGtransfer -36.9 kcal/mol
ΔGfold -21.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 859-882 (857-887)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: CSTN1:A4, PubMed

APRIO, Complex: CSTN1:APRIO.PRIO, PubMed

COHA1, Complex: COHA1:CSTN1, PubMed

Domains

AA: 169-258, PDBID: 3UBH, Subunit A, Seq Identity:32%, Cadherin domain

AA: 365-513, PDBID: 4QVS, Subunit A, Seq Identity:12%, Concanavalin A-like lectin/glucanases superfamily

UniProt annotation for CSTN1_HUMAN » Calsyntenin-1
FUNCTION: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity).

SUBUNIT: Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. The CTF1 chain interacts with PSEN1. The intracellular fragment AlcICD interacts with APBB1; this interaction stabilizes AlcICD metabolism. Interacts with KLC1 and APBB1 (By similarity).

TISSUE SPECIFICITY: Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level).

DOMAIN: The cytoplasmic domain is involved in interaction with APBA2, as well as the binding of synaptic Ca(2+).

UniProt features for CSTN1_HUMAN » Calsyntenin-1
SIGNAL 1 28
CHAIN 29 981 Calsyntenin-1.
CHAIN 29 825 Soluble Alc-alpha.
CHAIN 826 981 CTF1-alpha.
DOMAIN 38 164 Cadherin 1.
DOMAIN 165 265 Cadherin 2.
Amino Acid Sequence for CSTN1_HUMAN » Calsyntenin-1
MLRRPAPALA PAARLLLAGL LCGGGVWAAR VNKHKPWLEP TYHGIVTEND NTVLLDPPLI ALDKDAPLRF AESFEVTVTK EGEICGFKIH GQNVPFDAVV VDKSTGEGVI RSKEKLDCEL QKDYSFTIQA YDCGKGPDGT NVKKSHKATV HIQVNDVNEY APVFKEKSYK ATVIEGKQYD SILRVEAVDA DCSPQFSQIC SYEIITPDVP FTVDKDGYIK NTEKLNYGKE HQYKLTVTAY DCGKKRATED VLVKISIKPT CTPGWQGWNN RIEYEPGTGA LAVFPNIHLE TCDEPVASVQ ATVELETSHI GKGCDRDTYS EKSLHRLCGA AAGTAELLPS PSGSLNWTMG LPTDNGHDSD QVFEFNGTQA VRIPDGVVSV SPKEPFTISV WMRHGPFGRK KETILCSSDK TDMNRHHYSL YVHGCRLIFL FRQDPSEEKK YRPAEFHWKL NQVCDEEWHH YVLNVEFPSV TLYVDGTSHE PFSVTEDYPL HPSKIETQLV VGACWQEFSG VENDNETEPV TVASAGGDLH MTQFFRGNLA GLTLRSGKLA DKKVIDCLYT CKEGLDLQVL EDSGRGVQIQ AHPSQLVLTL EGEDLGELDK AMQHISYLNS RQFPTPGIRR LKITSTIKCF NEATCISVPP VDGYVMVLQP EEPKISLSGV HHFARAASEF ESSEGVFLFP ELRIISTITR EVEPEGDGAE DPTVQESLVS EEIVHDLDTC EVTVEGEELN HEQESLEVDM ARLQQKGIEV SSSELGMTFT GVDTMASYEE VLHLLRYRNW HARSLLDRKF KLICSELNGR YISNEFKVEV NVIHTANPME HANHMAAQPQ FVHPEHRSFV DLSGHNLANP HPFAVVPSTA TVVIVVCVSF LVFMIILGVF RIRAAHRRTM RDQDTGKENE MDWDDSALTI TVNPMETYED QHSSEEEEEE EEEEESEDGE EEDDITSAES ESSEEEEGEQ GDPQNATRQQ QLEWDDSTLS Y