CSPG5_HUMAN » Chondroitin sulfate proteoglycan 5

CSPG5_HUMAN » Chondroitin sulfate proteoglycan 5
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
CSPG5_HUMAN » Chondroitin sulfate proteoglycan 5 » Acidic leucine-rich EGF-like domain-containing brain protein;Neuroglycan C;
Hydrophobic Thickness 31.6 ± 4.4 Å
Tilt Angle 35 ± 4°
ΔGtransfer -26.5 kcal/mol
ΔGfold -24.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 419-446 (418-446)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 33-277, Chondroitin sulphate attachment domain

AA: 447-565, Neural chondroitin sulphate proteoglycan cytoplasmic domain

UniProt annotation for CSPG5_HUMAN » Chondroitin sulfate proteoglycan 5
FUNCTION: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.

SUBUNIT: Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC.

TISSUE SPECIFICITY: Restricted to brain (at protein level).

DEVELOPMENTAL STAGE: Expressed in brain of 3 months, 5 and 10- year-old individuals.

MISCELLANEOUS: Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage (By similarity).

UniProt features for CSPG5_HUMAN » Chondroitin sulfate proteoglycan 5
SIGNAL 1 30 Potential.
CHAIN 31 566 Chondroitin sulfate proteoglycan 5.
DOMAIN 371 413 EGF-like.
REGION 264 301 Interaction with TNC and TNR (By similarity).
REGION 442 460 Interaction with GOPC.
DISULFID 374 387 By similarity.
DISULFID 381 397 By similarity.
DISULFID 399 412 By similarity.
Amino Acid Sequence for CSPG5_HUMAN » Chondroitin sulfate proteoglycan 5
MGRAGGGGPG RGPPPLLLFL GAALVLASGA VPAREAGSAV EAEELVKGSP AWEPPANDTR EEAGPPAAGE DEASWTAPGG ELAGPEEVLQ ESAAVTGTAW LEADSPGLGG VTAEAGSGDA QALPATLQAP HEVLGQSIMP PAIPEATEAS GPPSPTPGDK LSPASELPKE SPLEVWLNLG GSTPDPQGPE LTYPFQGTLE PQPASDIIDI DYFEGLDGEG RGADLGSFPG SPGTSENHPD TEGETPSWSL LDLYDDFTPF DESDFYPTTS FYDDLDEEEE EEEDDKDAVG GGDLEDENEL LVPTGKPGLG PGTGQPTSRW HAVPPQHTLG SVPGSSIALR PRPGEPGRDL ASSENGTECR SGFVRHNGSC RSVCDLFPSY CHNGGQCYLV ENIGAFCRCN TQDYIWHKGM RCESIITDFQ VMCVAVGSAA LVLLLLFMMT VFFAKKLYLL KTENTKLRRT NKFRTPSELH NDNFSLSTIA EGSHPNVRKL CNTPRTSSPH ARALAHYDNV ICQDDPSAPH KIQEVLKSCL KEEESFNIQN SMSPKLEGGK GDQADLDVNC LQNNLT