CSMD2_HUMAN » CUB and sushi domain-containing protein 2

CSMD2_HUMAN » CUB and sushi domain-containing protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CSMD2_HUMAN » CUB and sushi domain-containing protein 2 » CUB and sushi multiple domains protein 2;
Hydrophobic Thickness 32.0 ± 2.1 Å
Tilt Angle 9 ± 3°
ΔGtransfer -26.2 kcal/mol
ΔGfold -22.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 3411-3432 (3408-3437)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 26-131, PDBID: 2QQK, Subunit A, Seq Identity:37%, CUB domain

AA: 139-196, PDBID: 1GHQ, Subunit C, Seq Identity:37%, Sushi repeat (SCR repeat)

AA: 202-303, PDBID: 3KQ4, Subunit B, Seq Identity:36%, CUB domain

AA: 343-400, PDBID: 2EHF, Subunit A, Seq Identity:44%, Sushi repeat (SCR repeat)

AA: 405-513, PDBID: 3KQ4, Subunit B, Seq Identity:33%, CUB domain

AA: 521-574, PDBID: 2EHF, Subunit A, Seq Identity:68%, Sushi repeat (SCR repeat)

AA: 578-683, PDBID: 2QQK, Subunit A, Seq Identity:37%, CUB domain

AA: 691-748, PDBID: 2A55, Subunit A, Seq Identity:37%, Sushi repeat (SCR repeat)

AA: 752-857, PDBID: 2QQK, Subunit A, Seq Identity:37%, CUB domain

AA: 867-920, PDBID: 1H03, Subunit P, Seq Identity:38%, Sushi repeat (SCR repeat)

AA: 924-1031, PDBID: 3KQ4, Subunit B, Seq Identity:40%, CUB domain

AA: 1039-1094, PDBID: 1H03, Subunit P, Seq Identity:35%, Sushi repeat (SCR repeat)

AA: 1098-1203, PDBID: 3KQ4, Subunit B, Seq Identity:38%, CUB domain

AA: 1211-1267, PDBID: 1H03, Subunit P, Seq Identity:39%, Sushi repeat (SCR repeat)

AA: 1271-1377, PDBID: 2QQK, Subunit A, Seq Identity:36%, CUB domain

AA: 1385-1441, PDBID: 2EHF, Subunit A, Seq Identity:33%, Sushi repeat (SCR repeat)

AA: 1445-1550, PDBID: 3KQ4, Subunit B, Seq Identity:41%, CUB domain

AA: 1558-1615, PDBID: 1G40, Subunit B, Seq Identity:44%, Sushi repeat (SCR repeat)

AA: 1619-1724, PDBID: 2QQK, Subunit A, Seq Identity:32%, CUB domain

AA: 1735-1792, PDBID: 2EHF, Subunit A, Seq Identity:39%, Sushi repeat (SCR repeat)

AA: 1796-1901, PDBID: 3KQ4, Subunit B, Seq Identity:39%, CUB domain

AA: 1909-1964, PDBID: 1G40, Subunit B, Seq Identity:36%, Sushi repeat (SCR repeat)

AA: 1968-2073, PDBID: 3KQ4, Subunit B, Seq Identity:36%, CUB domain

AA: 2123-2178, PDBID: 3ERB, Subunit A, Seq Identity:40%, Sushi repeat (SCR repeat)

AA: 2182-2286, PDBID: 2QQK, Subunit A, Seq Identity:35%, CUB domain

AA: 2294-2351, PDBID: 3ERB, Subunit A, Seq Identity:35%, Sushi repeat (SCR repeat)

AA: 2355-2463, PDBID: 2QQK, Subunit A, Seq Identity:32%, CUB domain

AA: 2468-2526, PDBID: 1GKG, Subunit A, Seq Identity:34%, Sushi repeat (SCR repeat)

AA: 2531-2588, PDBID: 1GKG, Subunit A, Seq Identity:39%, Sushi repeat (SCR repeat)

AA: 2591-2653, PDBID: 2YBY, Subunit A, Seq Identity:26%, Sushi repeat (SCR repeat)

AA: 2658-2711, PDBID: 2EHF, Subunit A, Seq Identity:43%, Sushi repeat (SCR repeat)

AA: 2716-2769, PDBID: 1H03, Subunit P, Seq Identity:43%, Sushi repeat (SCR repeat)

AA: 2774-2827, PDBID: 1G40, Subunit B, Seq Identity:40%, Sushi repeat (SCR repeat)

AA: 2835-2888, PDBID: 2EHF, Subunit A, Seq Identity:54%, Sushi repeat (SCR repeat)

AA: 2893-2947, PDBID: 2MCY, Subunit A, Seq Identity:36%, Sushi repeat (SCR repeat)

AA: 2952-3007, PDBID: 2EHF, Subunit A, Seq Identity:35%, Sushi repeat (SCR repeat)

AA: 3012-3065, PDBID: 3ZD1, Subunit B, Seq Identity:43%, Sushi repeat (SCR repeat)

AA: 3070-3123, PDBID: 2EHF, Subunit A, Seq Identity:43%, Sushi repeat (SCR repeat)

AA: 3131-3185, PDBID: 2OK5, Subunit A, Seq Identity:38%, Sushi repeat (SCR repeat)

AA: 3190-3245, PDBID: 1CKL, Subunit D, Seq Identity:34%, Sushi repeat (SCR repeat)

UniProt annotation for CSMD2_HUMAN » CUB and sushi domain-containing protein 2
TISSUE SPECIFICITY: Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus and fetal brain. Overexpressed in some head and neck cancer cell lines.
UniProt features for CSMD2_HUMAN » CUB and sushi domain-containing protein 2
CHAIN 1 3487 CUB and sushi domain-containing protein 2.
DOMAIN 26 134 CUB 1.
DOMAIN 137 198 Sushi 1.
DOMAIN 202 306 CUB 2.
DOMAIN 341 402 Sushi 2.
DOMAIN 405 516 CUB 3.
DOMAIN 519 576 Sushi 3.
DOMAIN 578 686 CUB 4.
DOMAIN 689 750 Sushi 4.
DOMAIN 752 860 CUB 5.
DOMAIN 865 922 Sushi 5.
DOMAIN 924 1034 CUB 6.
DOMAIN 1037 1096 Sushi 6.
DOMAIN 1098 1206 CUB 7.
DOMAIN 1209 1269 Sushi 7.
DOMAIN 1271 1380 CUB 8.
DOMAIN 1383 1443 Sushi 8.
DOMAIN 1445 1553 CUB 9.
DOMAIN 1556 1617 Sushi 9.
DOMAIN 1619 1727 CUB 10.
DOMAIN 1733 1794 Sushi 10.
DOMAIN 1796 1904 CUB 11.
DOMAIN 1907 1966 Sushi 11.
DOMAIN 1968 2076 CUB 12.
DOMAIN 2121 2180 Sushi 12.
DOMAIN 2182 2293 CUB 13.
DOMAIN 2292 2353 Sushi 13.
DOMAIN 2355 2466 CUB 14.
DOMAIN 2466 2528 Sushi 14.
DOMAIN 2529 2590 Sushi 15.
DOMAIN 2591 2655 Sushi 16.
DOMAIN 2656 2713 Sushi 17.
DOMAIN 2714 2771 Sushi 18.
DOMAIN 2772 2829 Sushi 19.
DOMAIN 2833 2890 Sushi 20.
DOMAIN 2891 2949 Sushi 21.
DOMAIN 2950 3009 Sushi 22.
DOMAIN 3010 3067 Sushi 23.
DOMAIN 3068 3125 Sushi 24.
DOMAIN 3129 3187 Sushi 25.
DOMAIN 3188 3247 Sushi 26.
DISULFID 26 52 By similarity.
DISULFID 139 179 By similarity.
DISULFID 165 196 By similarity.
DISULFID 202 228 By similarity.
DISULFID 343 383 By similarity.
DISULFID 369 400 By similarity.
DISULFID 405 431 By similarity.
DISULFID 521 561 By similarity.
DISULFID 547 574 By similarity.
DISULFID 578 604 By similarity.
DISULFID 691 732 By similarity.
DISULFID 717 748 By similarity.
DISULFID 752 778 By similarity.
DISULFID 867 907 By similarity.
DISULFID 893 920 By similarity.
DISULFID 924 950 By similarity.
DISULFID 1039 1079 By similarity.
DISULFID 1065 1094 By similarity.
DISULFID 1098 1124 By similarity.
DISULFID 1211 1252 By similarity.
DISULFID 1238 1267 By similarity.
DISULFID 1271 1298 By similarity.
DISULFID 1385 1425 By similarity.
DISULFID 1411 1441 By similarity.
DISULFID 1445 1471 By similarity.
DISULFID 1558 1598 By similarity.
DISULFID 1584 1615 By similarity.
DISULFID 1619 1645 By similarity.
DISULFID 1735 1775 By similarity.
DISULFID 1761 1792 By similarity.
DISULFID 1796 1822 By similarity.
DISULFID 1909 1949 By similarity.
DISULFID 1935 1964 By similarity.
DISULFID 1968 1994 By similarity.
DISULFID 2123 2163 By similarity.
DISULFID 2149 2178 By similarity.
DISULFID 2182 2208 By similarity.
DISULFID 2294 2336 By similarity.
DISULFID 2322 2351 By similarity.
DISULFID 2355 2383 By similarity.
DISULFID 2468 2509 By similarity.
DISULFID 2495 2526 By similarity.
DISULFID 2531 2573 By similarity.
DISULFID 2557 2588 By similarity.
DISULFID 2593 2638 By similarity.
DISULFID 2624 2653 By similarity.
DISULFID 2658 2698 By similarity.
DISULFID 2684 2711 By similarity.
DISULFID 2716 2756 By similarity.
DISULFID 2742 2769 By similarity.
DISULFID 2774 2814 By similarity.
DISULFID 2800 2827 By similarity.
DISULFID 2835 2875 By similarity.
DISULFID 2861 2888 By similarity.
DISULFID 2893 2934 By similarity.
DISULFID 2920 2947 By similarity.
DISULFID 2952 2994 By similarity.
DISULFID 2978 3007 By similarity.
DISULFID 3012 3052 By similarity.
DISULFID 3038 3065 By similarity.
DISULFID 3070 3110 By similarity.
DISULFID 3096 3123 By similarity.
DISULFID 3131 3172 By similarity.
DISULFID 3158 3185 By similarity.
DISULFID 3190 3232 By similarity.
DISULFID 3217 3245 By similarity.
Amino Acid Sequence for CSMD2_HUMAN » CUB and sushi domain-containing protein 2
MRLISIAPGP RWQVQSHHPR SAGQNCTFQL HGPNGTVESP GFPYGYPNYA NCTWTITAEE QHRIQLVFQS FALEEDFDVL SVFDGPPQPE NLRTRLTGFQ LPATIVSAAT TLSLRLISDY AVSAQGFHAT YEVLPSHTCG NPGRLPNGIQ QGSTFNLGDK VRYSCNLGFF LEGHAVLTCH AGSENSATWD FPLPSCRADD ACGGTLRGQS GIISSPHFPS EYHNNADCTW TILAELGDTI ALVFIDFQLE DGYDFLEVTG TEGSSLWFTG ASLPAPVISS KNWLRLHFTS DGNHRQRGFS AQYQVKKQIE LKSRGVKLMP SKDNSQKTSV LTQVGVSQGH NMCPDPGIPE RGKRLGSDFR LGSSVQFTCN EGYDLQGSKR ITCMKVSDMF AAWSDHRPVC RARMCDAHLR GPSGIITSPN FPIQYDNNAH CVWIITALNP SKVIKLAFEE FDLERGYDTL TVGDGGQDGD QKTVLYILTG TSVPDLIVST NHQMWLLFQT DGSGSSLGFK ASYEEIEQGS CGDPGIPAYG RREGSRFHHG DTLKFECQPA FELVGQKAIT CQKNNQWSAK KPGCVFSCFF NFTSPSGVVL SPNYPEDYGN HLHCVWLILA RPESRIHLAF NDIDVEPQFD FLVIKDGATA EAPVLGTFSG NQLPSSITSS GHVARLEFQT DHSTGKRGFN ITFTTFRHNE CPDPGVPVNG KRFGDSLQLG SSISFLCDEG FLGTQGSETI TCVLKEGSVV WNSAVLRCEA PCGGHLTSPS GTILSPGWPG FYKDALSCAW VIEAQPGYPI KITFDRFKTE VNYDTLEVRD GRTYSAPLIG VYHGTQVPQF LISTSNYLYL LFSTDKSHSD IGFQLRYETI TLQSDHCLDP GIPVNGQRHG NDFYVGALVT FSCDSGYTLS DGEPLECEPN FQWSRALPSC EALCGGFIQG SSGTILSPGF PDFYPNNLNC TWIIETSHGK GVFFTFHTFH LESGHDYLLI TENGSFTQPL RQLTGSRLPA PISAGLYGNF TAQVRFISDF SMSYEGFNIT FSEYDLEPCE EPEVPAYSIR KGLQFGVGDT LTFSCFPGYR LEGTARITCL GGRRRLWSSP LPRCVAECGN SVTGTQGTLL SPNFPVNYNN NHECIYSIQT QPGKGIQLKA RAFELSEGDV LKVYDGNNNS ARLLGVFSHS EMMGVTLNST SSSLWLDFIT DAENTSKGFE LHFSSFELIK CEDPGTPKFG YKVHDEGHFA GSSVSFSCDP GYSLRGSEEL LCLSGERRTW DRPLPTCVAE CGGTVRGEVS GQVLSPGYPA PYEHNLNCIW TIEAEAGCTI GLHFLVFDTE EVHDVLRIWD GPVESGVLLK ELSGPALPKD LHSTFNSVVL QFSTDFFTSK QGFAIQFSVS TATSCNDPGI PQNGSRSGDS WEAGDSTVFQ CDPGYALQGS AEISCVKIEN RFFWQPSPPT CIAPCGGDLT GPSGVILSPN YPEPYPPGKE CDWKVTVSPD YVIALVFNIF NLEPGYDFLH IYDGRDSLSP LIGSFYGSQL PGRIESSSNS LFLAFRSDAS VSNAGFVIDY TENPRESCFD PGSIKNGTRV GSDLKLGSSV TYYCHGGYEV EGTSTLSCIL GPDGKPVWNN PRPVCTAPCG GQYVGSDGVV LSPNYPQNYT SGQICLYFVT VPKDYVVFGQ FAFFHTALND VVEVHDGHSQ HSRLLSSLSG SHTGESLPLA TSNQVLIKFS AKGLAPARGF HFVYQAVPRT SATQCSSVPE PRYGKRLGSD FSVGAIVRFE CNSGYALQGS PEIECLPVPG ALAQWNVSAP TCVVPCGGNL TERRGTILSP GFPEPYLNSL NCVWKIVVPE GAGIQIQVVS FVTEQNWDSL EVFDGADNTV TMLGSFSGTT VPALLNSTSN QLYLHFYSDI SVSAAGFHLE YKTVGLSSCP EPAVPSNGVK TGERYLVNDV VSFQCEPGYA LQGHAHISCM PGTVRRWNYP PPLCIAQCGG TVEEMEGVIL SPGFPGNYPS NMDCSWKIAL PVGFGAHIQF LNFSTEPNHD YIEIRNGPYE TSRMMGRFSG SELPSSLLST SHETTVYFHS DHSQNRPGFK LEYQDLTYSH QISSFLRGFD LSELERTNST PPVAASYVWD LDPGCEAYEL QECPDPEPFA NGIVRGAGYN VGQSVTFECL PGYQLTGHPV LTCQHGTNRN WDHPLPKCEV PCGGNITSSN GTVYSPGFPS PYSSSQDCVW LITVPIGHGV RLNLSLLQTE PSGDFITIWD GPQQTAPRLG VFTRSMAKKT VQSSSNQVLL KFHRDAATGG IFAIAFSAYP LTKCPPPTIL PNAEVVTENE EFNIGDIVRY RCLPGFTLVG NEILTCKLGT YLQFEGPPPI CEVHCPTNEL LTDSTGVILS QSYPGSYPQF QTCSWLVRVE PDYNISLTVE YFLSEKQYDE FEIFDGPSGQ SPLLKALSGN YSAPLIVTSS SNSVYLRWSS DHAYNRKGFK IRYSAPYCSL PRAPLHGFIL GQTSTQPGGS IHFGCNAGYR LVGHSMAICT RHPQGYHLWS EAIPLCQALS CGLPEAPKNG MVFGKEYTVG TKAMYSCSEG YHLQAGAEAT AECLDTGLWS NRNVPPQCVP VTCPDVSSIS VEHGRWRLIF ETQYQFQAQL MLICDPGYYY TGQRVIRCQA NGKWSLGDST PTCRIISCGE LPIPPNGHRI GTLSVYGATA IFSCNSGYTL VGSRVRECMA NGLWSGSEVR CLAGHCGTPE PIVNGHINGE NYSYRGSVVY QCNAGFRLIG MSVRICQQDH HWSGKTPFCV LVSCGHPGSP PHSQMSGDSY TVGAVVRYSC IGKRTLVGNS TRMCGLDGHW TGSLPHCSGT SVGVCGDPGI PAHGIRLGDS FDPGTVMRFS CEAGHVLRGS SERTCQANGS WSGSQPECGV ISCGNPGTPS NARVVFSDGL VFSSSIVYEC REGYYATGLL SRHCSVNGTW TGSDPECLVI NCGDPGIPAN GLRLGNDFRY NKTVTYQCVP GYMMESHRVS VLSCTKDRTW NGTKPVCKAL MCKPPPLIPN GKVVGSDFMW GSSVTYACLE GYQLSLPAVF TCEGNGSWTG ELPQCFPVFC GDPGVPSRGR REDRGFSYRS SVSFSCHPPL VLVGSPRRFC QSDGTWSGTQ PSCIDPTLTT CADPGVPQFG IQNNSQGYQV GSTVLFRCQK GYLLQGSTTR TCLPNLTWSG TPPDCVPHHC RQPETPTHAN VGALDLPSMG YTLIYSCQEG FSLKGGSEHR TCKADGSWTG KPPICLEVRP SGRPINTARE PPLTQALIPG DVFAKNSLWK GAYEYQGKKQ PAMLRVTGFQ VANSKVNATM IDHSGVELHL AGTYKKEDFH LLLQVYQITG PVEIFMNKFK DDHWALDGHV SSESSGATFI YQGSVKGQGF GQFGFQRLDL RLLESDPESI GRHFASNSSS VAAAILVPFI ALIIAGFVLY LYKHRRRPKV PFNGYAGHEN TNVRATFENP MYDRNIQPTD IMASEAEFTV STVCTAV