CSMD1_HUMAN » CUB and sushi domain-containing protein 1

CSMD1_HUMAN » CUB and sushi domain-containing protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CSMD1_HUMAN » CUB and sushi domain-containing protein 1 » CUB and sushi multiple domains protein 1;
Hydrophobic Thickness 34.4 ± 2.6 Å
Tilt Angle 13 ± 12°
ΔGtransfer -23.1 kcal/mol
ΔGfold -17.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 3486-3510 (3485-3515)
Pathways none
PDB 2ehf (522-581)
OPM none
Complexes none
Interactions none
Domains

AA: 32-137, PDBID: 3KQ4, Subunit B, Seq Identity:39%, CUB domain

AA: 145-202, PDBID: 1GKG, Subunit A, Seq Identity:39%, Sushi repeat (SCR repeat)

AA: 208-309, PDBID: 3KQ4, Subunit B, Seq Identity:35%, CUB domain

AA: 349-407, PDBID: 1G40, Subunit B, Seq Identity:36%, Sushi repeat (SCR repeat)

AA: 412-520, PDBID: 3KQ4, Subunit B, Seq Identity:32%, CUB domain

AA: 528-581, PDBID: 2EHF, Subunit A, Seq Identity:100%, Sushi repeat (SCR repeat)

AA: 585-690, PDBID: 3KQ4, Subunit B, Seq Identity:39%, CUB domain

AA: 698-755, PDBID: 2A55, Subunit A, Seq Identity:37%, Sushi repeat (SCR repeat)

AA: 759-864, PDBID: 2QQK, Subunit A, Seq Identity:36%, CUB domain

AA: 874-927, PDBID: 2EHF, Subunit A, Seq Identity:36%, Sushi repeat (SCR repeat)

AA: 931-1038, PDBID: 3KQ4, Subunit B, Seq Identity:37%, CUB domain

AA: 1046-1101, PDBID: 3ERB, Subunit A, Seq Identity:38%, Sushi repeat (SCR repeat)

AA: 1105-1210, PDBID: 3KQ4, Subunit B, Seq Identity:36%, CUB domain

AA: 1218-1274, PDBID: 1H03, Subunit P, Seq Identity:33%, Sushi repeat (SCR repeat)

AA: 1278-1384, PDBID: 2QQK, Subunit A, Seq Identity:35%, CUB domain

AA: 1392-1448, PDBID: 2EHF, Subunit A, Seq Identity:38%, Sushi repeat (SCR repeat)

AA: 1452-1557, PDBID: 3KQ4, Subunit B, Seq Identity:41%, CUB domain

AA: 1565-1622, PDBID: 1G40, Subunit B, Seq Identity:39%, Sushi repeat (SCR repeat)

AA: 1626-1731, PDBID: 3KQ4, Subunit B, Seq Identity:30%, CUB domain

AA: 1742-1799, PDBID: 1G40, Subunit B, Seq Identity:36%, Sushi repeat (SCR repeat)

AA: 1803-1908, PDBID: 3KQ4, Subunit B, Seq Identity:37%, CUB domain

AA: 1916-1971, PDBID: 2OK5, Subunit A, Seq Identity:32%, Sushi repeat (SCR repeat)

AA: 1975-2080, PDBID: 3KQ4, Subunit B, Seq Identity:38%, CUB domain

AA: 2088-2143, PDBID: 3ERB, Subunit A, Seq Identity:42%, Sushi repeat (SCR repeat)

AA: 2147-2250, PDBID: 3KQ4, Subunit B, Seq Identity:36%, CUB domain

AA: 2259-2316, PDBID: 2YRA, Subunit A, Seq Identity:33%, Sushi repeat (SCR repeat)

AA: 2320-2428, PDBID: 3KQ4, Subunit B, Seq Identity:32%, CUB domain

AA: 2433-2491, PDBID: 1SRZ, Subunit A, Seq Identity:37%, Sushi repeat (SCR repeat)

AA: 2496-2553, PDBID: 2RLP, Subunit A, Seq Identity:37%, Sushi repeat (SCR repeat)

AA: 2573-2618, PDBID: 2OK5, Subunit A, Seq Identity:42%, Sushi repeat (SCR repeat)

AA: 2623-2676, PDBID: 1H03, Subunit P, Seq Identity:37%, Sushi repeat (SCR repeat)

AA: 2681-2734, PDBID: 1H03, Subunit P, Seq Identity:40%, Sushi repeat (SCR repeat)

AA: 2739-2792, PDBID: 1G40, Subunit B, Seq Identity:42%, Sushi repeat (SCR repeat)

AA: 2797-2855, PDBID: 1C1Z, Subunit A, Seq Identity:34%, Sushi repeat (SCR repeat)

AA: 2860-2913, PDBID: 1G40, Subunit B, Seq Identity:38%, Sushi repeat (SCR repeat)

AA: 2921-2974, PDBID: 2EHF, Subunit A, Seq Identity:47%, Sushi repeat (SCR repeat)

AA: 2979-3033, PDBID: 1H03, Subunit P, Seq Identity:36%, Sushi repeat (SCR repeat)

AA: 3038-3093, PDBID: 1C1Z, Subunit A, Seq Identity:37%, Sushi repeat (SCR repeat)

AA: 3098-3151, PDBID: 2XRB, Subunit A, Seq Identity:41%, Sushi repeat (SCR repeat)

AA: 3156-3209, PDBID: 2EHF, Subunit A, Seq Identity:43%, Sushi repeat (SCR repeat)

AA: 3217-3271, PDBID: 1H03, Subunit P, Seq Identity:36%, Sushi repeat (SCR repeat)

AA: 3276-3331, PDBID: 2MCY, Subunit A, Seq Identity:32%, Sushi repeat (SCR repeat)

UniProt annotation for CSMD1_HUMAN » CUB and sushi domain-containing protein 1
FUNCTION: Potential suppressor of squamous cell carcinomas.

TISSUE SPECIFICITY: Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus and fetal brain.

MISCELLANEOUS: CSMD1 may be a candidate for oral and oropharyngeal squamous cell carcinomas (OSCCs). PubMed:12696061 and PubMed:14506705 are however in disagreement: while PubMed:14506705 considers CSMD1 as a strong candidate for OSCCs, PubMed:12696061 thinks it is not.

UniProt features for CSMD1_HUMAN » CUB and sushi domain-containing protein 1
SIGNAL 1 26 Potential.
CHAIN 27 3565 CUB and sushi domain-containing protein 1.
DOMAIN 32 140 CUB 1.
DOMAIN 143 204 Sushi 1.
DOMAIN 208 312 CUB 2.
DOMAIN 347 409 Sushi 2.
DOMAIN 412 523 CUB 3.
DOMAIN 526 583 Sushi 3.
DOMAIN 585 693 CUB 4.
DOMAIN 696 757 Sushi 4.
DOMAIN 759 867 CUB 5.
DOMAIN 872 929 Sushi 5.
DOMAIN 931 1041 CUB 6.
DOMAIN 1044 1103 Sushi 6.
DOMAIN 1105 1213 CUB 7.
DOMAIN 1216 1276 Sushi 7.
DOMAIN 1278 1387 CUB 8.
DOMAIN 1390 1450 Sushi 8.
DOMAIN 1452 1560 CUB 9.
DOMAIN 1563 1624 Sushi 9.
DOMAIN 1626 1734 CUB 10.
DOMAIN 1740 1801 Sushi 10.
DOMAIN 1803 1911 CUB 11.
DOMAIN 1914 1973 Sushi 11.
DOMAIN 1975 2083 CUB 12.
DOMAIN 2086 2145 Sushi 12.
DOMAIN 2147 2258 CUB 13.
DOMAIN 2257 2318 Sushi 13.
DOMAIN 2320 2431 CUB 14.
DOMAIN 2431 2493 Sushi 14.
DOMAIN 2494 2555 Sushi 15.
DOMAIN 2556 2620 Sushi 16.
DOMAIN 2621 2678 Sushi 17.
DOMAIN 2679 2736 Sushi 18.
DOMAIN 2737 2794 Sushi 19.
DOMAIN 2795 2857 Sushi 20.
DOMAIN 2858 2915 Sushi 21.
DOMAIN 2919 2976 Sushi 22.
DOMAIN 2977 3035 Sushi 23.
DOMAIN 3036 3095 Sushi 24.
DOMAIN 3096 3153 Sushi 25.
DOMAIN 3154 3211 Sushi 26.
DOMAIN 3215 3273 Sushi 27.
DOMAIN 3274 3333 Sushi 28.
DISULFID 32 58 By similarity.
DISULFID 145 185 By similarity.
DISULFID 171 202 By similarity.
DISULFID 208 234 By similarity.
DISULFID 349 390 By similarity.
DISULFID 376 407 By similarity.
DISULFID 412 438 By similarity.
DISULFID 528 568 By similarity.
DISULFID 554 581 By similarity.
DISULFID 585 611 By similarity.
DISULFID 698 739 By similarity.
DISULFID 724 755 By similarity.
DISULFID 759 785 By similarity.
DISULFID 874 914 By similarity.
DISULFID 900 927 By similarity.
DISULFID 931 957 By similarity.
DISULFID 1046 1086 By similarity.
DISULFID 1072 1101 By similarity.
DISULFID 1105 1131 By similarity.
DISULFID 1218 1259 By similarity.
DISULFID 1245 1274 By similarity.
DISULFID 1278 1305 By similarity.
DISULFID 1392 1432 By similarity.
DISULFID 1418 1448 By similarity.
DISULFID 1452 1478 By similarity.
DISULFID 1565 1605 By similarity.
DISULFID 1591 1622 By similarity.
DISULFID 1626 1652 By similarity.
DISULFID 1742 1782 By similarity.
DISULFID 1768 1799 By similarity.
DISULFID 1803 1829 By similarity.
DISULFID 1916 1956 By similarity.
DISULFID 1942 1971 By similarity.
DISULFID 1975 2001 By similarity.
DISULFID 2088 2128 By similarity.
DISULFID 2114 2143 By similarity.
DISULFID 2147 2173 By similarity.
DISULFID 2259 2301 By similarity.
DISULFID 2287 2316 By similarity.
DISULFID 2320 2348 By similarity.
DISULFID 2433 2474 By similarity.
DISULFID 2460 2491 By similarity.
DISULFID 2496 2538 By similarity.
DISULFID 2522 2553 By similarity.
DISULFID 2558 2603 By similarity.
DISULFID 2589 2618 By similarity.
DISULFID 2623 2663 By similarity.
DISULFID 2649 2676 By similarity.
DISULFID 2681 2721 By similarity.
DISULFID 2707 2734 By similarity.
DISULFID 2739 2779 By similarity.
DISULFID 2765 2792 By similarity.
DISULFID 2797 2842 By similarity.
DISULFID 2828 2855 By similarity.
DISULFID 2860 2900 By similarity.
DISULFID 2886 2913 By similarity.
DISULFID 2921 2961 By similarity.
DISULFID 2947 2974 By similarity.
DISULFID 2979 3020 By similarity.
DISULFID 3006 3033 By similarity.
DISULFID 3038 3080 By similarity.
DISULFID 3064 3093 By similarity.
DISULFID 3098 3138 By similarity.
DISULFID 3124 3151 By similarity.
DISULFID 3156 3196 By similarity.
DISULFID 3182 3209 By similarity.
DISULFID 3217 3258 By similarity.
DISULFID 3244 3271 By similarity.
DISULFID 3276 3318 By similarity.
DISULFID 3303 3331 By similarity.
Amino Acid Sequence for CSMD1_HUMAN » CUB and sushi domain-containing protein 1
MTAWRRFQSL LLLLGLLVLC ARLLTAAKGQ NCGGLVQGPN GTIESPGFPH GYPNYANCTW IIITGERNRI QLSFHTFALE ENFDILSVYD GQPQQGNLKV RLSGFQLPSS IVSTGSILTL WFTTDFAVSA QGFKALYEVL PSHTCGNPGE ILKGVLHGTR FNIGDKIRYS CLPGYILEGH AILTCIVSPG NGASWDFPAP FCRAEGACGG TLRGTSSSIS SPHFPSEYEN NADCTWTILA EPGDTIALVF TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH RRKGFNAQFQ VKKAIELKSR GVKMLPSKDG SHKNSVLSQG GVALVSHMCL DPGIPENGRR AGSDFSRVGA NVQFSCEDNY VLQGSKSITC QRVTETLAAW SDHRPICRAR TCGSNLRGPS GVITSPNYPV QYEDNAHCVW VITTTDPDKV IKLAFEEFEL ERGYDTLTVG DAGKVGDTRS VLYVLTGSSV PDLIVSMSNQ MWLHLQSDDS IGSPGFKAVY QEIEKGGCGD PGIPAYGKRT GSSFLHGDTL TFECPAAFEL VGERVITCQQ NNQWSGNKPS CVFSCFFNFT ASSGIILSPN YPEEYGNNMN CVWLIISEPG SRIHLIFNDF DVEPQFDFLA VKDDGISDIT VLGTFSGNEV PSQLASSGHI VRLEFQSDHS TTGRGFNITY TTFGQNECHD PGIPINGRRF GDRFLLGSSV SFHCDDGFVK TQGSESITCI LQDGNVVWSS TVPRCEAPCG GHLTASSGVI LPPGWPGYYK DSLHCEWIIE AKPGHSIKMT FDRFQTEVNY DTLEVRDGPA SSSPLIGEYH GTQAPQFLIS TGNFMYLLFT TDNSRSSIGF LIHYESVTLE SDSCLDPGIP VNGHRHGGDF GIRSTVTFSC DPGYTLSDDE PLVCERNHQW NHALPSCDAL CGGYIQGKSG TVLSPGFPDF YPNSLNCTWT IEVSHGKGVQ MIFHTFHLES SHDYLLITED GSFSEPVARL TGSVLPHTIK AGLFGNFTAQ LRFISDFSIS YEGFNITFSE YDLEPCDDPG VPAFSRRIGF HFGVGDSLTF SCFLGYRLEG ATKLTCLGGG RRVWSAPLPR CVAECGASVK GNEGTLLSPN FPSNYDNTHE CIYKIETEAG KGIHLRTRSF QLFEGDTLKV YDGKDSSSRP LGTFTKNELL GLILNSTSNH LWLEFNTNGS DTDQGFQLTY TSFDLVKCED PGIPNYGYRI RDEGHFTDTV VLYSCNPGYA MHGSNTLTCL SGDRRVWDKP LPSCIAECGG QIHAATSGRI LSPGYPAPYD NNLHCTWIIE ADPGKTISLH FIVFDTEMAH DILKVWDGPV DSDILLKEWS GSALPEDIHS TFNSLTLQFD SDFFISKSGF SIQFSTSIAA TCNDPGMPQN GTRYGDSREA GDTVTFQCDP GYQLQGQAKI TCVQLNNRFF WQPDPPTCIA ACGGNLTGPA GVILSPNYPQ PYPPGKECDW RVKVNPDFVI ALIFKSFNME PSYDFLHIYE GEDSNSPLIG SYQGSQAPER IESSGNSLFL AFRSDASVGL SGFAIEFKEK PREACFDPGN IMNGTRVGTD FKLGSTITYQ CDSGYKILDP SSITCVIGAD GKPSWDQVLP SCNAPCGGQY TGSEGVVLSP NYPHNYTAGQ ICLYSITVPK EFVVFGQFAY FQTALNDLAE LFDGTHAQAR LLSSLSGSHS GETLPLATSN QILLRFSAKS GASARGFHFV YQAVPRTSDT QCSSVPEPRY GRRIGSEFSA GSIVRFECNP GYLLQGSTAL HCQSVPNALA QWNDTIPSCV VPCSGNFTQR RGTILSPGYP EPYGNNLNCI WKIIVTEGSG IQIQVISFAT EQNWDSLEIH DGGDVTAPRL GSFSGTTVPA LLNSTSNQLY LHFQSDISVA AAGFHLEYKT VGLAACQEPA LPSNSIKIGD RYMVNDVLSF QCEPGYTLQG RSHISCMPGT VRRWNYPSPL CIATCGGTLS TLGGVILSPG FPGSYPNNLD CTWRISLPIG YGAHIQFLNF STEANHDFLE IQNGPYHTSP MIGQFSGTDL PAALLSTTHE TLIHFYSDHS QNRQGFKLAY QAYELQNCPD PPPFQNGYMI NSDYSVGQSV SFECYPGYIL IGHPVLTCQH GINRNWNYPF PRCDAPCGYN VTSQNGTIYS PGFPDEYPIL KDCIWLITVP PGHGVYINFT LLQTEAVNDY IAVWDGPDQN SPQLGVFSGN TALETAYSST NQVLLKFHSD FSNGGFFVLN FHAFQLKKCQ PPPAVPQAEM LTEDDDFEIG DFVKYQCHPG YTLVGTDILT CKLSSQLQFE GSLPTCEAQC PANEVRTGSS GVILSPGYPG NYFNSQTCSW SIKVEPNYNI TIFVDTFQSE KQFDALEVFD GSSGQSPLLV VLSGNHTEQS NFTSRSNQLY LRWSTDHATS KKGFKIRYAA PYCSLTHPLK NGGILNRTAG AVGSKVHYFC KPGYRMVGHS NATCRRNPLG MYQWDSLTPL CQAVSCGIPE SPGNGSFTGN EFTLDSKVVY ECHEGFKLES SQQATAVCQE DGLWSNKGKP PMCKPVACPS IEAQLSEHVI WRLVSGSLNE YGAQVLLSCS PGYYLEGWRL LRCQANGTWN IGDERPSCRV ISCGSLSFPP NGNKIGTLTV YGATAIFTCN TGYTLVGSHV RECLANGLWS GSETRCLAGH CGSPDPIVNG HISGDGFSYR DTVVYQCNPG FRLVGTSVRI CLQDHKWSGQ TPVCVPITCG HPGNPAHGFT NGSEFNLNDV VNFTCNTGYL LQGVSRAQCR SNGQWSSPLP TCRVVNCSDP GFVENAIRHG QQNFPESFEY GMSILYHCKK GFHLLGSSAL TCMANGLWDR SLPKCLAISC GHPGVPANAV LTGELFTYGA VVHYSCRGSE SLIGNDTRVC QEDSHWSGAL PHCTGNNPGF CGDPGTPAHG SRLGDDFKTK SLLRFSCEMG HQLRGSPERT CLLNGSWSGL QPVCEAVSCG NPGTPTNGMI VSSDGILFSS SVIYACWEGY KTSGLMTRHC TANGTWTGTA PDCTIISCGD PGTLANGIQF GTDFTFNKTV SYQCNPGYVM EAVTSATIRC TKDGRWNPSK PVCKAVLCPQ PPPVQNGTVE GSDFRWGSSI SYSCMDGYQL SHSAILSCEG RGVWKGEIPQ CLPVFCGDPG IPAEGRLSGK SFTYKSEVFF QCKSPFILVG SSRRVCQADG TWSGIQPTCI DPAHNTCPDP GTPHFGIQNS SRGYEVGSTV FFRCRKGYHI QGSTTRTCLA NLTWSGIQTE CIPHACRQPE TPAHADVRAI DLPTFGYTLV YTCHPGFFLA GGSEHRTCKA DMKWTGKSPV CKSKGVREVN ETVTKTPVPS DVFFVNSLWK GYYEYLGKRQ PATLTVDWFN ATSSKVNATF SEASPVELKL TGIYKKEEAH LLLKAFQIKG QADIFVSKFE NDNWGLDGYV SSGLERGGFT FQGDIHGKDF GKFKLERQDP LNPDQDSSSH YHGTSSGSVA AAILVPFFAL ILSGFAFYLY KHRTRPKVQY NGYAGHENSN GQASFENPMY DTNLKPTEAK AVRFDTTLNT VCTVVG