CSF1_HUMAN » Macrophage colony-stimulating factor 1

CSF1_HUMAN » Macrophage colony-stimulating factor 1
Magnify CSF1_HUMAN » Macrophage colony-stimulating factor 1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CSF1_HUMAN » Macrophage colony-stimulating factor 1 » CSF-1; M-CSF; MCSF; Lanimostim;
Hydrophobic Thickness 29.6 ± 3.0 Å
Tilt Angle 11 ± 9°
ΔGtransfer -38.7 kcal/mol
ΔGfold -17.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 496-520 (494-524)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

Osteoclast differentiation (KEGG)

PI3K-Akt signaling pathway (KEGG)

Rheumatoid arthritis (KEGG)

TNF signaling pathway (KEGG)

PDB 3uf2 (A/B...=33-181), 1hmc (A/B=36-181), 3uez (E/F/G/H=33-181), 4fa8 (E/F/G=36-180), 4adf (G/H...=33-181)
OPM none
Complexes

CSF1:CSF1R_MOUSE

CSF1:CSF1_HUMAN

Interactions

1B07, Complex: 1B07:CSF1, PubMed

CSF1R, Complex: CSF1:CSF1R, PDBID: 3EJJ, PubMed

CSF1, Complex: Homodimer of macrophage colony-stimulating factor 1, PDBID: 1HMC

TNFA, Complex: CSF1:TNFA, PubMed

Domains

AA: 41-180, PDBID: 3UEZ, Subunit G, Seq Identity:100%, Macrophage colony stimulating factor-1 (CSF-1)

UniProt annotation for CSF1_HUMAN » Macrophage colony-stimulating factor 1
FUNCTION: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

SUBUNIT: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

DISEASE: Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.

DISEASE: Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.

UniProt features for CSF1_HUMAN » Macrophage colony-stimulating factor 1
SIGNAL 1 32
CHAIN 33 554 Macrophage colony-stimulating factor 1.
CHAIN 33 ? Processed macrophage colony-stimulating factor 1.
REGION 406 426 O-glycosylated at one site.
DISULFID 39 122
DISULFID 63 63 Interchain.
DISULFID 80 171
DISULFID 134 178
DISULFID 189 189 Interchain.
DISULFID 191 191 Interchain.
Amino Acid Sequence for CSF1_HUMAN » Macrophage colony-stimulating factor 1
MTAPGAAGRC PPTTWLGSLL LLVCLLASRS ITEEVSEYCS HMIGSGHLQS LQRLIDSQME TSCQITFEFV DQEQLKDPVC YLKKAFLLVQ DIMEDTMRFR DNTPNAIAIV QLQELSLRLK SCFTKDYEEH DKACVRTFYE TPLQLLEKVK NVFNETKNLL DKDWNIFSKN CNNSFAECSS QDVVTKPDCN CLYPKAIPSS DPASVSPHQP LAPSMAPVAG LTWEDSEGTE GSSLLPGEQP LHTVDPGSAK QRPPRSTCQS FEPPETPVVK DSTIGGSPQP RPSVGAFNPG MEDILDSAMG TNWVPEEASG EASEIPVPQG TELSPSRPGG GSMQTEPARP SNFLSASSPL PASAKGQQPA DVTGTALPRV GPVRPTGQDW NHTPQKTDHP SALLRDPPEP GSPRISSLRP QGLSNPSTLS AQPQLSRSHS SGSVLPLGEL EGRRSTRDRR SPAEPEGGPA SEGAARPLPR FNSVPLTDTG HERQSEGSSS PQLQESVFHL LVPSVILVLL AVGGLLFYRW RRRSHQEPQR ADSPLEQPEG SPLTQDDRQV ELPV